Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells.

Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells.
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渗透激活的嗜碱性粒细胞和人肺肥大细胞释放的组胺和花生四烯酸代谢物的解离。

DOI:
10.1164/ajrccm/141.4_pt_1.960
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发表时间:
1990
期刊:
The American review of respiratory disease
影响因子:
--
通讯作者:
Lichtenstein,LM
Lichtenstein,LM
中科院分区:
--
文献类型:
--
作者:
Eggleston,PA;Kagey-Sobotka,A;Proud,D;AdkinsonJr,NF;Lichtenstein,LM

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在大多数刺激激活后,嗜碱性粒细胞和人肺肥大细胞同时释放组胺和花生四烯酸代谢物。检查高渗激活,两种细胞类型都显示释放组胺,但很少或不释放白三烯C.或D.(LTC./D.),并且在肥大细胞的情况下,释放很少或不释放前列腺素O2 (PG02)。此外,高渗缓冲液能够防止 LTC./LTD 的形成。在同时添加或2、5或10分钟后添加抗·lgE刺激的嗜碱性粒细胞中,添加抗·lgE。 lgE。 PGD​​2 的分解代谢和
Upon activation by most stimuli, basophils and human lung mast cells simultaneously release histamine and arachidonic acid metabolites. Hyperosmolar activation was examined, and both cell types were shown to release histamine but little or no leukotriene C. or D.(LTC./D.) and, in the case ot mast cells, little or no prostaglandin O2 (PG02). In addition, hyperosmolar buffers were capable of preventing the formation ot LTC./LTD. In basophils stimulated by anti· lgE when added simultaneously, or 2, 5, or 10 min atter, the addition ot anti. lgE. Catabolism ot PGD2 and
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