XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma.
XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma.
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DOI：
10.4049/jimmunol.181.8.5386
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发表时间：
2008-10-15
期刊：
影响因子：
--
通讯作者：
Nadeau KC
中科院分区：
文献类型：
--
作者：
Nguyen KD;Fohner A;Booker JD;Dong C;Krensky AM;Nadeau KC
趋化因子介导的调节细胞亚群在炎症过程中向气道的募集和增强其活性是过敏性哮喘（AA）治疗发展的潜在策略。在这项研究中，我们的目的是探讨XCL 1，一种与免疫抑制和过敏相关的趋化因子，对AA中CD 4 + CD 25 highCD 127 low/−调节性T细胞（Treg）功能的作用。流式细胞术和PCR分析显示，与健康对照和非过敏性哮喘对应物相比，AA Treg中XCL 1和XCR 1表达减少。XCL 1表达的减少与AA中Treg的次优调节功能相关。有趣的是，与重组人XCL 1孵育通过上调XCL 1和Treg功能的主要效应分子的表达显著增加Treg介导的抑制和细胞毒性。总之，这些结果表明，XCL 1表达失调和AA中Treg活性降低之间存在关联，以及XCL 1在逆转疾病中Treg功能缺陷中的潜在作用。
Chemokine-mediated recruitment of regulatory cell subsets to the airway during inflammation and enhancement of their activities are potential strategies for therapeutic development in allergic asthma (AA). In this study, we aim to explore the role of XCL1, a chemokine associated with immune suppression and allergy, on CD4+CD25highCD127low/− regulatory T cell (Treg) function in AA. Flow cytometry and PCR analysis showed a reduction in XCL1 and XCR1 expression in AA Treg compared with healthy control and nonallergic asthmatic counterparts. This reduction in XCL1 expression was associated with the suboptimal regulatory function of Treg in AA. Interestingly, incubation with recombinant human XCL1 significantly increased Treg-mediated suppression and cytotoxicity by up-regulating expression of XCL1 and chief effector molecules of Treg function. Altogether, these results suggest an association between dysregulated XCL1 expression and reduced Treg activities in AA, as well as a potential role of XCL1 in reversing defective Treg function in the disease.
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影响因子：
4.9
作者：
Hasegawa H;Inoue A;Muraoka M;Yamanouchi J;Miyazaki T;Yasukawa M
通讯作者：
Yasukawa M
影响因子：
14.2
作者：
Bellinghausen, I;Klostermann, B;Saloga, J
通讯作者：
Saloga, J
DOI：
10.1084/jem.20060155
发表时间：
2006-11-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Strickland DH;Stumbles PA;Zosky GR;Subrata LS;Thomas JA;Turner DJ;Sly PD;Holt PG
通讯作者：
Holt PG
DOI：
10.1164/rccm.200208-960oc
发表时间：
2004-04-01
影响因子：
24.7
作者：
Castro, M;Bloch, SR;Holtzman, MJ
通讯作者：
Holtzman, MJ
影响因子：
6.1
作者：
Grindebacke, H;Wing, K;Rudin, A
通讯作者：
Rudin, A