Altered power spectra in antisocial males during rest as a function of cocaine dependence: A network analysis.
Altered power spectra in antisocial males during rest as a function of cocaine dependence: A network analysis.
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DOI：
10.1016/j.pscychresns.2020.111235
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发表时间：
2021-03-30
期刊：
影响因子：
--
通讯作者：
Shane MS
中科院分区：
文献类型：
--
作者：
Simard I;Denomme WJ;Shane MS
在特定的静息状态网络（RSN）中已经注意到罪犯神经振荡的频谱功率异常;然而，还没有研究评估可卡因依赖、药物使用严重程度和精神病特征对这些异常的影响。为此，本研究比较了两组罪犯（有和没有DSM-IV-TR可卡因依赖诊断）和非罪犯对照组之间的休息相关功率谱特征。结果表明，这两个罪犯组呈现较低的低频功率比（LFPR）的分数（即在所有RSN）比非罪犯。LFPR分数的这些差异被发现是由于两个罪犯组与非罪犯组相比，高频功率更高（0.15-0.25 Hz;在八个调查网络中的七个内）和低频功率降低（0.01-0.10 Hz;在八个调查网络中的六个内）。因此，可卡因依赖性和非依赖性罪犯显示一贯异常的神经振荡，这表明这些振荡异常可以作为一个广泛的罪犯状态的神经生物学标记。罪犯的LFPR水平与可卡因使用的年限相关，但与精神病特征的水平无关。这些研究结果补充了我们的知识，物质使用对罪犯的休息状态活动的影响，此外，他们提供了进一步的指示，评估与药物使用和反社会人格特征相关的共享/独特的方差的重要性。
Abnormalities in the spectral power of offenders’ neural oscillations have been noted within select Resting-State Networks (RSNs); however, no study has yet evaluated the influence of cocaine dependence, drug use severity, and psychopathic traits on these abnormalities. To this end, the present study compared rest-related power spectral characteristics between two groups of offenders (with and without a DSM-IV-TR cocaine-dependence diagnosis) and a non-offender control group. Results indicated that both offender groups presented with lower low frequency power ratio (LFPR) scores (i.e. across all RSNs) than non-offenders. These differences in LFPR scores were found to be due to both higher high-frequency power (0.15-0.25 Hz; within seven of eight investigated networks) and decreased low-frequency power (0.01-0.10 Hz; within six of eight investigated networks) in both offender groups compared to non-offenders. Thus, both cocaine-dependent and non-dependent offenders displayed consistently abnormal neural oscillations, suggesting that these oscillatory abnormalities could serve as a broad neurobiological marker of offender status. Offenders’ LFPR levels correlated with lifetime years of cocaine use, but not with the level of psychopathic traits. These findings supplement our knowledge of the influence of substance use on resting-state activity in offenders; moreover, they provide further indication of the importance of evaluating shared/unique variance associated with drug use and antisocial personality traits.
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