Neuroimaging of psychopathy and antisocial behavior: a targeted review.

Neuroimaging of psychopathy and antisocial behavior: a targeted review.
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DOI:
10.1007/s11920-009-0086-x
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发表时间:
2010-02
影响因子:
6.7
通讯作者:
Blair, R. J. R.
Blair, R. J. R.
中科院分区:
医学2区
文献类型:
--
作者:
Blair, R. J. R.

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本文的目的是提供一个有选择性的和有针对性的审查精神病倾向和反社会行为的神经影像学文献,并探讨在何种程度上,这些文献支持最近的认知神经科学模型的精神病和反社会行为。文献显示,那些表现出反应性而非工具性攻击风险增加的个体,其杏仁核对情感唤起刺激的反应会增加。这与这样的建议是一致的,即这些人对威胁或挫折事件的反应强烈到不适当的程度。相反,有精神病倾向的人对情绪刺激或情绪学习模式的杏仁核和眶额皮质反应减少。这与这些人在基本形式的情感学习和决策方面面临困难的建议是一致的。
The goal of this article is to provide a selective and targeted review of the neuroimaging literature on psychopathic tendencies and antisocial behavior and to explore the extent to which this literature supports recent cognitive neuroscientific models of psychopathy and antisocial behavior. The literature reveals that individuals who present with an increased risk for reactive, but not instrumental, aggression show increased amygdala responses to emotionally evocative stimuli. This is consistent with suggestions that such individuals are primed to respond strongly to an inappropriate extent to threatening or frustrating events. In contrast, individuals with psychopathic tendencies show decreased amygdala and orbitofrontal cortex responses to emotionally provocative stimuli or during emotional learning paradigms. This is consistent with suggestions that such individuals face difficulties with basic forms of emotional learning and decision making.
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发表时间: 2008-04-15
期刊: NEUROIMAGE
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de Oliveira-Souza, Ricardo;Hare, Robert D.;Moll, Jorge
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