Association of brain-derived neurotrophic factor gene Val66Met polymorphism with primary dysmenorrhea.
Association of brain-derived neurotrophic factor gene Val66Met polymorphism with primary dysmenorrhea.
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DOI：
10.1371/journal.pone.0112766
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hsieh JC
中科院分区：
文献类型：
--
作者：
Lee LC;Tu CH;Chen LF;Shen HD;Chao HT;Lin MW;Hsieh JC
原发性痛经（PDM）是育龄妇女最常见的月经周期相关问题，与消极情绪有关。月经疼痛和消极情绪是否有遗传基础仍不清楚。脑源性神经营养因子（BDNF）在中枢致敏的产生中起关键作用，并导致慢性疼痛。BDNF也与压力相关的情绪障碍有关。我们在99名台湾（亚洲）PDM（20-30岁）和101名年龄匹配的健康女性对照中筛选和基因分型BDNF Val 66 Met多态性（rs6265）。我们发现，有一个显着更高的频率的脑源性神经营养因子Val 66 Met多态性的Met等位基因在PDM组。此外，与瓦尔携带者状态相比，BDNF Met/Met纯合性与PDM具有显著更强的关联。随后对亚组进行行为/激素评估（PDM = 78，对照 = 81;符合纵向多模式神经成像成套研究的条件）显示，在月经期，BDNF Met/Met纯合PDM比瓦尔携带者PDM表现出更高的月经疼痛评分（感觉维度）和更焦虑的情绪。虽然是初步的，我们的研究表明，BDNF Val 66 Met多态性与PDM在台湾（亚洲）的人，和BDNF Met/Met纯合性可能与PDM的风险增加。我们的数据还表明BDNF Val 66 Met多态性可能是PDM中月经疼痛和疼痛相关情绪的调节因子。没有热过敏可能意味着种族归属。我们的研究结果需要进一步的遗传和神经科学调查PDM。
Primary dysmenorrhea (PDM), the most prevalent menstrual cycle-related problem in women of reproductive age, is associated with negative moods. Whether the menstrual pain and negative moods have a genetic basis remains unknown. Brain-derived neurotrophic factor (BDNF) plays a key role in the production of central sensitization and contributes to chronic pain conditions. BDNF has also been implicated in stress-related mood disorders. We screened and genotyped the BDNF Val66Met polymorphism (rs6265) in 99 Taiwanese (Asian) PDMs (20–30 years old) and 101 age-matched healthy female controls. We found that there was a significantly higher frequency of the Met allele of the BDNF Val66Met polymorphism in the PDM group. Furthermore, BDNF Met/Met homozygosity had a significantly stronger association with PDM compared with Val carrier status. Subsequent behavioral/hormonal assessments of sub-groups (PDMs = 78, controls = 81; eligible for longitudinal multimodal neuroimaging battery studies) revealed that the BDNF Met/Met homozygous PDMs exhibited a higher menstrual pain score (sensory dimension) and a more anxious mood than the Val carrier PDMs during the menstrual phase. Although preliminary, our study suggests that the BDNF Val66Met polymorphism is associated with PDM in Taiwanese (Asian) people, and BDNF Met/Met homozygosity may be associated with an increased risk of PDM. Our data also suggest the BDNF Val66Met polymorphism as a possible regulator of menstrual pain and pain-related emotions in PDM. Absence of thermal hypersensitivity may connote an ethnic attribution. The presentation of our findings calls for further genetic and neuroscientific investigations of PDM.
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影响因子：
10.6
作者：
Bath, Kevin G.;Chuang, Jocelyn;Spencer-Segal, Joanna L.;Amso, Dima;Altemus, Margaret;McEwen, Bruce S.;Lee, Francis S.
通讯作者：
Lee, Francis S.
影响因子：
7.4
作者：
Giamberardino, MA;Berkley, KJ;Vecchiet, L
通讯作者：
Vecchiet, L
影响因子：
3.1
作者：
AMODEI, N;NELSONGRAY, RO
通讯作者：
NELSONGRAY, RO
影响因子：
13.3
作者：
Abu, JI;Konje, JC
通讯作者：
Konje, JC
影响因子：
7.2
作者：
Granot, M;Yarnitsky, D;Zimmer, EZ
通讯作者：
Zimmer, EZ