Common and specific liability to addiction: approaches to association studies of opioid addiction.
Common and specific liability to addiction: approaches to association studies of opioid addiction.
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DOI：
10.1016/j.drugalcdep.2012.03.026
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发表时间：
2012-06
影响因子：
4.2
通讯作者：
Kreek, Mary Jeanne
中科院分区：
文献类型：
--
作者：
Nielsen, David A.;Kreek, Mary Jeanne
类阿片成瘾，无论是对海洛因和吗啡等阿片剂，还是对类阿片的非医疗使用，都是全世界的一个主要问题。虽然药物引起的和环境因素对于发展阿片类成瘾的脆弱性至关重要，但现在已知个体的遗传背景也起着重要作用。这篇文章的总体目标是解决的共同和具体的负债成瘾的背景下，一种成瘾，阿片类药物成瘾的研究方法。对识别可能在阿片类药物成瘾发展中发挥作用的遗传变异的文献进行了综述。据报道，大量的遗传变异与阿片类药物成瘾有关。在任何报告的GWAS研究中均未发现对海洛因成瘾易感性具有显著效应量的单一变异。似乎存在大量变异体的复杂相互作用，有些罕见，有些常见，它们与环境相互作用，并对特定的滥用药物作出反应，增加了发展阿片成瘾的脆弱性。尽管在获得用于遗传研究的大量良好表型队列方面存在固有的困难，但据报道，新的发现正被用于将可检验的假设发展为阿片类成瘾的生物学基础。
Opioid addiction, whether to opiates such as heroin and morphine, and/or to non-medical use of opioids, is a major problem worldwide. Although drug-induced and environmental factors are essential for the vulnerability to develop opioid addiction, the genetic background of an individual is now known also to play a substantial role. The overall goal of this article is to address the common and specific liabilities to addiction in the context of approaches to studies of one addiction, opioid addiction. Literature on identifying genetic variants that may play a role in the development of opioid addiction was reviewed. A substantial number of genetic variants have been reported to be associated with opioid addiction. No single variant has been found in any of the reported GWAS studies with a substantial effect size on the vulnerability to develop heroin addiction. It appears that there is a complex interaction of a large number of variants, some rare, some common, which interact with the environment and in response to specific drugs of abuse to increase the vulnerability of developing opioid addiction. In spite of the inherent difficulties in obtaining large well-phenotyped cohorts for genetic studies, new findings have been reported that are being used to develop testable hypotheses into the biological basis of opioid addiction.
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影响因子：
11
作者：
Adams, J;Crosbie, J;Barr, CL
通讯作者：
Barr, CL
DOI：
10.1002/ajmg.b.30510
发表时间：
2007-09-05
影响因子：
2.8
作者：
Gerra, G.;Leonardi, C.;Donnini, C.
通讯作者：
Donnini, C.
DOI：
10.1016/j.bbrc.2006.12.151
发表时间：
2007-03-02
影响因子：
3.1
作者：
Douet, Vanessa;Heller, Matthew B.;Le Saux, Olivier
通讯作者：
Le Saux, Olivier
影响因子：
15.9
作者：
Alikhani-Koopaei, R;Fouladkou, F;Frey, BM
通讯作者：
Frey, BM
DOI：
10.1016/j.molbrainres.2005.07.008
发表时间：
2005-10-31
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Cheng, CY;Hong, CJ;Tsai, SJ
通讯作者：
Tsai, SJ