The role of mediator complex subunit 19 in human diseases
The role of mediator complex subunit 19 in human diseases
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介质复合物亚基19在人类疾病中的作用
DOI：
10.1177/15353702211011701
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发表时间：
2021-05
影响因子：
3.2
通讯作者：
Yali Zhou
中科院分区：
文献类型：
--
作者：
Yuting Zhang;Peifang Qin;Linlin Tian;Jianguo Yan;Yali Zhou
介体是一种进化保守的多蛋白质复合体，作为真核生物转录机制中的基本连接物，调节不同蛋白质之间的相互作用。它与RNA聚合酶II相互作用，参与基因表达过程。介质复合体亚基19或氧调节3，或肺癌转移相关蛋白1位于介体复合体的头部，它是一种多蛋白共激活因子，通过DNA转录因子诱导RNA聚合酶II的转录。它是一个与肿瘤相关的基因，在转录调控、细胞增殖和细胞凋亡中发挥重要作用，与肺癌、膀胱癌、皮肤癌等肿瘤的发生发展密切相关。本文从介体复合体19的结构入手，综述其在肿瘤进展、脂肪代谢、药物治疗中的作用，以及目前备受关注的新型冠状病毒，提示介体复合体19在临床疾病的发生发展中具有广泛的应用前景。作为一种肿瘤相关基因，介质复合体亚单位19在肿瘤生长调控中的作用和机制对肿瘤的诊断、预后和治疗具有重要意义。
Mediator is an evolutionarily conserved multi-protein complex that mediates the interaction between different proteins as a basic linker in the transcription mechanism of eukaryotes. It interacts with RNA polymerase II and participates in the process of gene expression. Mediator complex subunit 19 or regulation by oxygen 3, or lung cancer metastasis-related protein 1 is located at the head of the mediator complex; it is a multi-protein co-activator that induces the transcription of RNA polymerase II by DNA transcription factors. It is a tumor-related gene that plays an important role in transcriptional regulation, cell proliferation, and apoptosis and is closely related to the occurrence and development of the cancers of the lung, bladder, skin, etc. Here, we used the structure of mediator complex subunit 19 to review its role in tumor progression, fat metabolism, drug therapy, as well as the novel coronavirus, which has attracted much attention at present, suggesting that mediator complex subunit 19 has broad application in the occurrence and development of clinical diseases. As a tumor-related gene, the role and mechanism of mediator complex subunit 19 in the regulation of tumor growth could be of great significance for the diagnosis, prognosis, and treatment of mediator complex subunit 19 -related tumors.
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影响因子：
7
作者：
Imberg-Kazdan K;Ha S;Greenfield A;Poultney CS;Bonneau R;Logan SK;Garabedian MJ
通讯作者：
Garabedian MJ
影响因子：
16
作者：
M. Cosma;Silvia Panizza;K. Nasmyth
通讯作者：
M. Cosma;Silvia Panizza;K. Nasmyth
介导复合物亚基 19 的敲低可抑制前列腺癌细胞的生长和侵袭
影响因子：
3.7
作者：
Yu S;Wang Y;Yuan H;Zhao H;Lv W;Chen J;Wan F;Liu D;Gao Z;Wu J
通讯作者：
Wu J
影响因子：
64.5
作者：
Robinson PJ;Trnka MJ;Bushnell DA;Davis RE;Mattei PJ;Burlingame AL;Kornberg RD
通讯作者：
Kornberg RD
影响因子：
13.6
作者：
Trobaugh DW;Klimstra WB
通讯作者：
Klimstra WB