The contribution of the cardiomyocyte to tissue inflammation in cardiomyopathies.
The contribution of the cardiomyocyte to tissue inflammation in cardiomyopathies.
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心肌细胞在心肌病组织炎症中的作用。
DOI：
10.1016/j.cophys.2020.10.003
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发表时间：
2021-03
影响因子：
2.5
通讯作者：
Brown JH
中科院分区：
文献类型：
--
作者：
Ninh VK;Brown JH
心脏损伤触发急性免疫反应，通过激活代偿机制驱动组织愈合和重塑。随着时间的推移，重塑和炎症变成慢性，并产生不良影响，导致心脏功能下降，最终导致心力衰竭。心脏炎症的特点是心脏常驻细胞和循环白细胞募集之间的动态空间和时间串扰。直到最近，心肌细胞还没有被认为是心脏炎症的直接诱因。它现在已经成为急性免疫反应的关键发起者，通过其产生细胞因子的能力，也可能同步白细胞在损伤后的募集。本文将对心肌细胞在缺血性和非缺血性损伤的急性免疫反应中的作用及其可能影响心脏重构和衰竭过程的机制进行综述。
Cardiac injury triggers an acute immune response that drives tissue healing and remodeling via the activation of compensatory mechanisms. Over time, remodeling and inflammation become chronic and have adverse effects that lead to a depression of cardiac function and eventual heart failure. Cardiac inflammation is characterized by dynamic spatial and temporal crosstalk between the resident cells of the heart and recruitment of circulating leukocytes. Until recently, the cardiomyocyte has not been accepted as a direct contributor to cardiac inflammation. It has now emerged as a key initiator of the acute immune response via its ability to produce cytokines and may also synchronize leukocyte recruitment post-injury. This review will focus on the role of the cardiomyocyte in the acute immune response to ischemic and non-ischemic injury and the mechanisms by which it may influence the course of cardiac remodeling and failure.
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影响因子：
37.8
作者：
Kong P;Shinde AV;Su Y;Russo I;Chen B;Saxena A;Conway SJ;Graff JM;Frangogiannis NG
通讯作者：
Frangogiannis NG
IRF3和I型干扰物为心肌梗死提供了致命的反应。
影响因子：
82.9
作者：
King KR;Aguirre AD;Ye YX;Sun Y;Roh JD;Ng RP Jr;Kohler RH;Arlauckas SP;Iwamoto Y;Savol A;Sadreyev RI;Kelly M;Fitzgibbons TP;Fitzgerald KA;Mitchison T;Libby P;Nahrendorf M;Weissleder R
通讯作者：
Weissleder R
影响因子：
9
作者：
Marwick JA;Mills R;Kay O;Michail K;Stephen J;Rossi AG;Dransfield I;Hirani N
通讯作者：
Hirani N
影响因子：
3.6
作者：
Prame Kumar K;Nicholls AJ;Wong CHY
通讯作者：
Wong CHY
DOI：
10.1073/pnas.1424236112
发表时间：
2015-06-09
影响因子：
11.1
作者：
Chen, Wei-Yu;Hong, Jaewoo;Lee, Richard T.
通讯作者：
Lee, Richard T.