Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease.
Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease.
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DOI：
10.1007/s00441-017-2753-2
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发表时间：
2018-03
影响因子：
3.6
通讯作者：
Wong CHY
中科院分区：
文献类型：
--
作者：
Prame Kumar K;Nicholls AJ;Wong CHY
中性粒细胞被认为是高度通用和复杂的细胞，显示从头合成能力和潜在的延长寿命。新兴的概念，如中性粒细胞异质性和可塑性已经表明，在病理条件下，中性粒细胞可以分化成离散的子集定义不同的表型和功能特征。事实上，这些新描述的嗜中性粒细胞亚群无疑将增加嗜中性粒细胞和其他免疫细胞类型之间已经复杂的相互作用，以实现有效的免疫应答。中性粒细胞和单核细胞/巨噬细胞之间的相互作用使宿主能够有效地防御和消除外来病原体。然而，越来越清楚的是，如果不严格监管，这些相互作用可能对宿主有害。在这篇综述中，我们将探讨中性粒细胞和单核细胞/巨噬细胞在稳态，在急性炎症和各种疾病的设置中的功能合作。我们将在动脉粥样硬化形式的心血管疾病的背景下讨论这一点，动脉粥样硬化是一种主要发生在肾脏的自身免疫性疾病，以及肠道的独特肠道免疫反应不符合典型免疫系统的规范。
Neutrophils are becoming recognized as highly versatile and sophisticated cells that display de novo synthetic capacity and potentially prolonged lifespan. Emerging concepts such as neutrophil heterogeneity and plasticity have revealed that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional characteristics. Indeed, these newly described neutrophil subsets will undoubtedly add to the already complex interactions between neutrophils and other immune cell types for an effective immune response. The interactions between neutrophils and monocytes/macrophages enable the host to efficiently defend against and eliminate foreign pathogens. However, it is also becoming increasingly clear that these interactions can be detrimental to the host if not tightly regulated. In this review, we will explore the functional cooperation of neutrophil and monocytes/macrophages in homeostasis, during acute inflammation and in various disease settings. We will discuss this in the context of cardiovascular disease in the form of atherosclerosis, an autoimmune disease mainly occurring in the kidneys, as well as the unique intestinal immune response of the gut that does not conform to the norms of the typical immune system.
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