Breaking up prolonged sitting reduces postprandial glucose and insulin responses.
Breaking up prolonged sitting reduces postprandial glucose and insulin responses.
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DOI：
10.2337/dc11-1931
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发表时间：
2012-05
期刊：
影响因子：
16.2
通讯作者：
Owen N
中科院分区：
文献类型：
--
作者：
Dunstan DW;Kingwell BA;Larsen R;Healy GN;Cerin E;Hamilton MT;Shaw JE;Bertovic DA;Zimmet PZ;Salmon J;Owen N
观察性研究表明，延长的坐姿与心脏代谢风险标记具有有益的关联，但是我们需要进行干预研究以调查随意性。 - 强度步行。
超重/肥胖的成年人（n = 19），年龄45-65岁，被招募为一个随机的三个周期，三处处理的急性跨界试验：1）不间断的坐姿；每20分钟和3分钟，在最初的2小时内坐着2分钟后，将2分钟的现代强度散步。 （IAUC）在测试饮料（75 g葡萄糖，50 g脂肪）后5小时用于葡萄糖和胰岛素（平均[95％CI]）。
两种活动破裂条件后的葡萄糖IAUC（mmol/l）×H均降低（光：5.2 [4.1-6.6]；中度：4.9 [3.8–6.1];两个p <0.01）与不间断的坐姿相比（6.9 [5.5 [5.5 [5.5 [5.5 [5.5]胰岛素IAUC（pmol/l）×H也在两种破裂的条件下还会降低（光：633.6 [552.4-727.1]；中度：637.6 [555.5-731.9]，p <0.0001）不间断的坐姿（828.6 [722.0–950.9]）。
在超重/肥胖的成年人中，用短或中等强度的步行降低了餐后葡萄糖和胰岛素水平，这可能会改善葡萄糖代谢，并有可能是降低心血管风险的重要公共卫生和临床干预策略。
Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. Overweight/obese adults (n = 19), aged 45–65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95% CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. The glucose iAUC (mmol/L) ⋅ h after both activity-break conditions was reduced (light: 5.2 [4.1–6.6]; moderate: 4.9 [3.8–6.1]; both P < 0.01) compared with uninterrupted sitting (6.9 [5.5–8.7]). Insulin iAUC (pmol/L) ⋅ h was also reduced with both activity-break conditions (light: 633.6 [552.4–727.1]; moderate: 637.6 [555.5–731.9], P < 0.0001) compared with uninterrupted sitting (828.6 [722.0–950.9]). Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.
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DOI：
10.1097/00005768-199805000-00021
发表时间：
1998-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Freedson, PS;Melanson, E;Sirard, J
通讯作者：
Sirard, J
影响因子：
7.7
作者：
Hamilton, Marc T.;Hamilton, Deborah G.;Zderic, Theodore W.
通讯作者：
Zderic, Theodore W.
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
影响因子：
39.3
作者：
Healy, Genevieve N.;Matthews, Charles E.;Owen, Neville
通讯作者：
Owen, Neville
影响因子：
3
作者：
Achten, J;Jeukendrup, AE
通讯作者：
Jeukendrup, AE