Association between 9p21 genomic markers and ischemic stroke risk: evidence based on 21 studies.
Association between 9p21 genomic markers and ischemic stroke risk: evidence based on 21 studies.
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DOI：
10.1371/journal.pone.0090255
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Ni X;Zhang J
流行病学研究表明，遗传因素对缺血性卒中风险有贡献，但具体的遗传变异仍不清楚。最近的独立研究报道了冠心病和位于染色体9 p21的单核苷酸多态性（SNP）（rs 10757278和代理SNP）之间的关联。鉴于中风是心肌梗死后的常见并发症，已在不同种族人群中进行了几项验证研究，以调查相同的位点是否与缺血性中风（IS）相关，但结果并不一致。为了研究这种不一致性并得出更精确的关系估计，对来自21项研究的34，128例病例和153，428例对照进行了荟萃分析。还评估了异质性的潜在来源，包括种族、样本量、对照来源和缺血性卒中亚型。总体而言，rs 10757278的IS的汇总比值比为1.11（95% CI：1.07-1.15，P<10−5）。在按种族进行的亚组分析中，发现东亚人（3188例病例和4503例对照; OR = 1.14，95%CI：1.07-1.21，P<10−5）和高加索人（30505例病例和145153例对照; OR = 1.08，95%CI：1.04-1.12，P<10−5）的多态性风险显著增加;而在所有遗传模型中，未发现非洲裔美国人（435例病例和3772例对照; OR = 0.97，95%CI：0.63-1.51，P = 0.90）的显著相关性。 在按IS亚型进行的亚组分析中，仅在大血管卒中组中检测到显著相关性，而在小血管或心源性栓塞性卒中中没有显著相关性。当按样本大小和对照来源分层时，在所有遗传模型中发现多态性的风险显著增加。该荟萃分析提供了染色体9 p21处遗传变异与IS关联的准确和全面的估计，但这些关联在不同种族人群中存在差异。
Epidemiological studies indicate a genetic contribution to ischemic stroke risk, but specific genetic variants remain unknown. Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21 (rs10757278 and proxy SNPs). Given that stroke is a common complication after myocardial infarction, several validation studies have been conducted among various ethnic populations to investigate if the same loci was associated with ischemic stroke (IS), but the results have been inconsistent. To investigate this inconsistency and derive a more precise estimation of the relationship, a meta-analysis of 34,128 cases and 153,428 controls from 21 studies was performed. Potential sources of heterogeneity including ethnicity, sample size, control source and ischemic stroke subtypes were also assessed. Overall, the summary odds ratio of IS was 1.11 (95% CI: 1.07–1.15, P<10−5) for rs10757278. In the subgroup analysis by ethnicity, significantly increased risks were found in East Asians (3188 cases and 4503 controls; OR = 1.14, 95% CI: 1.07–1.21, P<10−5) and Caucasians (30505 cases and 145153controls; OR = 1.08, 95% CI: 1.04–1.12, P<10−5) for the polymorphism; while no significant associations were found among African Americans (435 cases and 3772 controls; OR = 0.97, 95% CI: 0.63–1.51, P = 0.90) in all genetic models. In the subgroup analyses by IS subtypes, significant association was detected only in large vessel stroke group, while no significant associations among small vessel or cardioembolic stroke. When stratified by sample size, and control source, significantly increased risks were found for the polymorphism in all genetic models. This meta-analysis provides accurate and comprehensive estimates of the association of genetic variant at chromosome 9p21 and IS, but these associations vary in different ethnic populations.
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影响因子：
30.8
作者：
Helgadottir, Anna;Thorleifsson, Gudmar;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
5.1
作者：
Olsson, S.;Jood, K.;Jern, C.
通讯作者：
Jern, C.
影响因子：
5.2
作者：
Lemmens, Robin;Abboud, Sherine;Goris, An
通讯作者：
Goris, An
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
8.3
作者：
Matarin, Mar;Brown, W. Mark;Meschia, James F.
通讯作者：
Meschia, James F.