Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes.
Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes.
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DOI：
10.1080/08916934.2021.2012165
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发表时间：
2022-03
期刊：
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
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作者：
Progressive destruction of pancreatic islet β-cells by immune cells is a primary feature of type 1 diabetes (T1D) and therapies that can restore the functional β-cell mass are needed to alleviate disease progression. Here, we report the use of mesenchymal stromal/stem cells (MSCs) for the production and delivery of Gastrin, a peptide-hormone which is produced by intestinal cells and fetal islets and can increase β-Cell mass, to promote protection from T1D. A single injection of syngeneic MSCs that were engineered to express Gastrin (Gastrin-MSCs) caused a significant delay in hyperglycemia in non-obese diabetic (NOD) mice compared to engineered control-MSCs. Similar treatment of early-hyperglycemic mice caused the restoration of euglycemia for a considerable duration, and these therapeutic effects were associated with protection of, and/or higher frequencies of, insulin producing islets and less severe insulitis. While the overall immune cell phenotype was not affected profoundly upon treatment using Gastrin-MSCs or upon in vitro culture, pancreatic lymph node cells from Gastrin-MSC treated mice, upon ex vivo challenge with self-antigen, showed a Th2 and Th17 bias, and diminished the diabetogenic property in NOD-Rag1 deficient mice suggesting a disease protective immune modulation under Gastrin-MSC treatment associated protection from hyperglycemia. Overall, this study shows the potential of production and delivery of Gastrin in vivo, by MSCs, in protecting insulin producing β-cells and ameliorating the disease progression in T1D.
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影响因子：
3
作者：
GITTES, GK;RUTTER, WJ;DEBAS, HT
通讯作者：
DEBAS, HT
胰腺β细胞在啮齿动物和人糖尿病中表达胎儿胰岛激素胃癌。
影响因子：
7.7
作者：
Dahan T;Ziv O;Horwitz E;Zemmour H;Lavi J;Swisa A;Leibowitz G;Ashcroft FM;In't Veld P;Glaser B;Dor Y
通讯作者：
Dor Y
DOI：
10.4049/jimmunol.0900803
发表时间：
2009-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fiorina P;Jurewicz M;Augello A;Vergani A;Dada S;La Rosa S;Selig M;Godwin J;Law K;Placidi C;Smith RN;Capella C;Rodig S;Adra CN;Atkinson M;Sayegh MH;Abdi R
通讯作者：
Abdi R
影响因子：
4.4
作者：
Gyurko, Robert;Siqueira, Camille C.;Van Dyke, Thomas E.
通讯作者：
Van Dyke, Thomas E.
影响因子：
7.7
作者：
Abdi R;Fiorina P;Adra CN;Atkinson M;Sayegh MH
通讯作者：
Sayegh MH