One Year Follow-Up of Taste-Related Reward Associations with Weight Loss Suggests a Critical Time to Mitigate Weight Regain Following Bariatric Surgery.
One Year Follow-Up of Taste-Related Reward Associations with Weight Loss Suggests a Critical Time to Mitigate Weight Regain Following Bariatric Surgery.
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DOI：
10.3390/nu13113943
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发表时间：
2021-11-04
期刊：
影响因子：
5.9
通讯作者：
Steele KE
中科院分区：
文献类型：
--
作者：
Smith KR;Aghababian A;Papantoni A;Veldhuizen MG;Kamath V;Harris C;Moran TH;Carnell S;Steele KE
背景：体重恢复是肥胖患者关注的问题。我们以前证明，味觉相关的奖励处理与Roux-en-Y胃旁路术（RYGB）后6个月的体重减轻结果相关，但与垂直袖状胃切除术（VSG）无关。在这里，我们评估了这些味觉因素是否能持续预测术后一年的体重减轻和体重恢复。研究方法：参加减肥手术后味觉偏好纵向研究的成年女性在手术后一年完成了行为和神经影像学评估。结果如下：相对于VSG，RYGB产生更好的体重减轻，从VSG后6个月至1年观察到体重恢复和更大的体重减轻变异性。在RYGB中，术后2周时对高脂肪的喜好从基线的变化仍然是体重减轻的预测因素，但其他预测因素并不存在。术后一年，平均喜欢率反弹至基线水平，自我报告的食物渴望和饮食去抑制与体重减轻相关。结论：RYGB重置中脑边缘通路中奖励刺激的神经处理所导致的初始解剖和代谢变化似乎是暂时的，并且可能取决于术后进食行为返回到术前致肥胖倾向。术后6个月可能是实施干预措施以减轻体重增加的关键窗口。
Background: Weight regain is a concerning issue in bariatric patients. We previously demonstrated that taste-related reward processing was associated with six-month weight loss outcomes following Roux-en-Y gastric bypass (RYGB) but not vertical sleeve gastrectomy (VSG). Here, we assessed whether these taste factors persisted in predicting weight loss, and weight regain, at one year post-surgery. Methods: Adult women enrolled in a longitudinal study of taste preferences following bariatric surgery completed behavioral and neuroimaging assessments at one year post-surgery. Results: RYGB produced better weight loss relative to VSG, with weight regain and greater weight loss variability observed from six months to one year post-VSG. Changes in liking for high fat at 2 weeks post-surgery from baseline remained a predictor of weight loss in RYGB, but other predictors did not persist. Average liking ratings rebounded to baseline and higher self-reported food cravings and dietary disinhibition correlated with poorer weight loss at one year post-surgery. Conclusion: Initial anatomical and metabolic changes resulting from RYGB that reset neural processing of reward stimuli in the mesolimbic pathway appear to be temporary and may be contingent upon post-operative eating behaviors returning to preoperative obesogenic tendencies. Six months post-surgery may be a critical window for implementing interventions to mitigate weight gain.
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