Mechanisms of dopamine transporter regulation in normal and disease states.
Mechanisms of dopamine transporter regulation in normal and disease states.
复制标题
在正常和疾病状态下多巴胺转运蛋白调节的机制。
DOI：
10.1016/j.tips.2013.07.005
复制
发表时间：
2013-09
影响因子：
13.8
通讯作者：
Foster, James D.
中科院分区：
文献类型：
--
作者：
Vaughan, Roxanne A.;Foster, James D.
关键词：
多巴胺转运体(DAT)通过驱动突触前神经元重新摄取细胞外递质来控制多巴胺(DA)神经传递的时空动态。许多疾病，如抑郁症、双相情感障碍、帕金森氏病和注意缺陷多动障碍，都与DA水平异常有关，这表明DAT是其病因之一。用于治疗这些疾病的药物和许多成瘾药物都针对DAT，并通过抑制递质重摄取来增强多巴胺能信号。我们现在了解到DAT的运输和结合特性是由复杂和重叠的机制调节的，这些机制为神经元提供了响应生理需求调节DA清除的能力。这些过程由内源性信号通路控制，并受外源性转运蛋白配体的影响，表明它们对正常的神经传递、药物滥用和疾病治疗具有重要意义。越来越多的证据支持DA障碍中这些机制的破坏，暗示了疾病病因中运输的失调，并暗示这些过程可能是DA可用性的治疗操纵点。
The dopamine transporter (DAT) controls the spatial and temporal dynamics of dopamine (DA) neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. Many diseases such as depression, bipolar disorder, Parkinson’s disease, and attention deficit hyperactivity disorder are associated with abnormal DA levels, implicating DAT as a factor in their etiology. Medications used to treat these disorders and many addictive drugs target DAT and enhance dopaminergic signaling by suppressing transmitter reuptake. We now understand that transport and binding properties of DAT are regulated by complex and overlapping mechanisms that provide neurons the ability to modulate DA clearance in response to physiological demands. These processes are controlled by endogenous signaling pathways and affected by exogenous transporter ligands, demonstrating their importance for normal neurotransmission, drug abuse, and disease treatments. Increasing evidence supports the disruption of these mechanisms in DA disorders, implicating dysregulation of transport in disease etiologies and suggesting these processes as potential points for therapeutic manipulation of DA availability.
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影响因子：
3.3
作者：
Cervinski, M. A.;Foster, J. D.;Vaughan, R. A.
通讯作者：
Vaughan, R. A.
DOI：
10.1523/jneurosci.5094-09.2010
发表时间：
2010-04-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bowton E;Saunders C;Erreger K;Sakrikar D;Matthies HJ;Sen N;Jessen T;Colbran RJ;Caron MG;Javitch JA;Blakely RD;Galli A
通讯作者：
Galli A
影响因子：
4.9
作者：
Dichter GS;Damiano CA;Allen JA
通讯作者：
Allen JA
影响因子：
4.8
作者：
Cervinski, MA;Foster, JD;Vaughan, RA
通讯作者：
Vaughan, RA
影响因子：
4.7
作者：
Boudanova, Ekaterina;Navaroli, Deanna A.;Melikian, Haley E.
通讯作者：
Melikian, Haley E.