Compartmentalization and regulation of GTP in control of cellular phenotypes.
Compartmentalization and regulation of GTP in control of cellular phenotypes.
复制标题
DOI：
10.1016/j.molmed.2022.05.012
复制
发表时间：
2022-09
影响因子：
13.6
通讯作者：
Nikiforov, Mikhail A.
中科院分区：
文献类型：
--
作者：
Wolff, David W.;Bianchi-Smiraglia, Anna;Nikiforov, Mikhail A.
Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has substantial biological effects, underlining the need to better understand the function of GTP levels in regulation of cellular processes and the significance of targeting GTP biosynthesis enzymes for therapeutic intervention. Our current understanding of spatiotemporal regulation of GTP metabolism and its role in physiological and pathological cellular processes is far from complete. Novel methodologies such as genetically encoded sensors of free GTP offered insights into intracellular distribution and function of GTP molecules. In the current review we provide analysis of recent discoveries in the field of GTP metabolism and evaluate the key enzymes as molecular targets.
登录
查看更多内容
影响因子：
--
作者：
Barfeld SJ;Fazli L;Persson M;Marjavaara L;Urbanucci A;Kaukoniemi KM;Rennie PS;Ceder Y;Chabes A;Visakorpi T;Mills IG
通讯作者：
Mills IG
影响因子：
8.8
作者：
Depaoli MR;Karsten F;Madreiter-Sokolowski CT;Klec C;Gottschalk B;Bischof H;Eroglu E;Waldeck-Weiermair M;Simmen T;Graier WF;Malli R
通讯作者：
Malli R
影响因子：
48
作者：
Bianchi-Smiraglia A;Rana MS;Foley CE;Paul LM;Lipchick BC;Moparthy S;Moparthy K;Fink EE;Bagati A;Hurley E;Affronti HC;Bakin AV;Kandel ES;Smiraglia DJ;Feltri ML;Sousa R;Nikiforov MA
通讯作者：
Nikiforov MA
PI5P4K在癌症中的扩大作用：一个有前途的可毒靶。
影响因子：
3.5
作者：
Arora, Gurpreet K.;Palamiuc, Lavinia;Emerling, Brooke M.
通讯作者：
Emerling, Brooke M.
影响因子：
3.7
作者：
Carcamo WC;Satoh M;Kasahara H;Terada N;Hamazaki T;Chan JY;Yao B;Tamayo S;Covini G;von Mühlen CA;Chan EK
通讯作者：
Chan EK