The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage.
The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage.
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DOI：
10.1016/j.ydbio.2009.10.037
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发表时间：
2010-04-15
影响因子：
2.7
通讯作者：
Davidson, Eric H.
中科院分区：
文献类型：
--
作者：
Peter, Isabelle S.;Davidson, Eric H.
由于早期的分化过程，海胆胚胎最终形成各种中胚层细胞系和由前、中、后肠组成的肠道。基因调控网络（grn）编码了生物体规格的进展以及整体空间组织。我们分析了GRN驱动内胚层规格直到原胚形成的开始，并提出了决定这一过程的机制，直到囊胚中期阶段。在这个阶段，胚胎由两种不同的内胚层前体细胞组成，它们具有不同的调节状态。其中一种细胞系，即植物细胞系，产生内胚层和中胚层细胞类型。这些细胞命运的分离是由中胚层GRN的空间受限激活叠加在veg2后代中普遍激活的内胚层GRN上引起的。在这里，我们将调控相互作用的结构与调控基因表达的空间限制结合起来，模拟内胚层发育的逻辑控制。
As the result of early specification processes, sea urchin embryos eventually form various mesodermal cell lineages and a gut consisting of fore-, mid- and hindgut. The progression of specification as well as the overall spatial organization of the organism is encoded in its gene regulatory networks (GRNs). We have analyzed the GRN driving endoderm specification up to the onset of gastrulation and present in this paper the mechanisms which determine this process up to mid-blastula stage. At this stage, the embryo consists of two separate lineages of endoderm precursor cells with distinct regulatory states. One of these lineages, the veg2 cell lineage, gives rise to endoderm and mesoderm cell types. The separation of these cell fates is initiated by the spatially confined activation of the mesoderm GRN superimposed on a generally activated endoderm GRN within veg2 descendants. Here we integrate the architecture of regulatory interactions with the spatial restriction of regulatory gene expression to model the logic control of endoderm development.
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DOI：
10.1073/pnas.2235868100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hinman, VF;Nguyen, AT;Davidson, EH
通讯作者：
Davidson, EH
影响因子：
2.7
作者：
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Davidson, EH
影响因子：
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通讯作者：
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影响因子：
2.5
作者：
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通讯作者：
Davidson, Eric H.
影响因子：
14.8
作者：
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