Adrenergic function in patients with panic anxiety.
Adrenergic function in patients with panic anxiety.
复制标题
惊恐焦虑患者的肾上腺素能功能。
作者：
RandolphM. Nesse;O. Cameron;G. Curtis;Daisy S. McCann;M. Huber
β-肾上腺素能受体敏感性的增加可以解释惊恐障碍的许多方面。我们通过比较14名患者和6名正常对照受试者来验证这一假设。对照组和8名患者在4小时的方案中采集了14份血液样本，并测量了心率和BP，该方案包括仰卧休息，姿势和等长运动刺激，以及一系列多达7次递增的盐酸异丙肾上腺素静脉推注剂量。其他6名患者仅在休息时进行研究。患者静息心率显著升高，血浆肾上腺素、皮质醇和生长激素水平显著升高，血浆去甲肾上腺素水平轻度升高，对异丙肾上腺素的心率反应降低。这些结果表明，β-肾上腺素能受体反应不增加，并可能减少，在惊恐障碍患者。受体下调可能是由于这些患者表现出的肾上腺素能功能增加，即使没有惊恐发作。
Increased beta-adrenergic receptor sensitivity could account for many aspects of panic disorder. We tested this hypothesis by comparing 14 patients with six normal control subjects. The controls and eight patients had 14 blood samples taken, and heart rate and BP measured, during a four-hour protocol that included supine rest, a posture and isometric exercise stimulus, and a series of up to seven logarithmically increasing bolus intravenous doses of isoproterenol hydrochloride. The other six patients were studied only at rest. Patients had markedly elevated resting heart rate, substantially elevated levels of plasma epinephrine, cortisol, and growth hormone, mildly elevated plasma norepinephrine levels, and decreased heart rate responses to isoproterenol. These results suggest that beta-adrenergic receptor response is not increased, and may be decreased, in patients with panic disorder. Receptor down-regulation could result from the increased adrenergic function that these patients demonstrate, even in the absence of panic attacks.
新生儿 6-羟基多巴胺治疗后脑部 β-肾上腺素能受体的发育。
影响因子：
3.8
作者：
Lorton,D;Bartolome,J;Slotkin,TA;Davis,JN
通讯作者：
Davis,JN
影响因子：
5.9
作者：
PFEIFER, MA;WEINBERG, CR;HALTER, JB
通讯作者：
HALTER, JB