Energy Metabolism of Osteocytes.
Energy Metabolism of Osteocytes.
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DOI：
10.1007/s11914-021-00688-6
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发表时间：
2021-08
影响因子：
4.3
通讯作者：
Guntur AR
中科院分区：
文献类型：
--
作者：
Karthik V;Guntur AR
In this review, we provide a recent update on bioenergetic pathways in osteocytes and identify potential future areas of research interest. Studies have identified a role for regulation of bone formation and bone resorption through osteocyte mechanosensing and osteocyte secreted factors, placing an emphasis on the energy metabolism of bone cells like chondrocytes, osteoblasts and osteoclasts. Nevertheless, there is a paucity of studies on the bioenergetics and energy metabolism of osteocytes, which are required for the regulation of bone remodeling. Osteocytes are cells of the osteoblast lineage embedded in bone. The osteocyte lacunocanalicular network within the skeletal matrix is exposed to a unique hypoxic environment. Therefore, the bioenergetic requirements of these cells could differ from other bone cells due to its location in the ossified matrix and its role in bone regulation transduced by mechanical signals. Recent findings provide some evidence that metabolism of these cells is dependent on their location due to the substrates present in the microenvironment and metabolic cues from stress pathways. Both glycolysis (glucose metabolism) and oxidative phosphorylation (mitochondrial dynamics, ROS generation) affect osteocyte function and viability. There is some evidence that glucose metabolism in osteocytes can be driven by hypoxia. The role of PTH and PTHrP in bone anabolism and resorption, along with glucose transport and glycolytic mechanisms need to be explored further in osteocytes in homeostasis and disease models. Mitochondrial metabolism has a role in osteocyte bioenergetics through substrate utilization, location of the osteocyte in the bone cortex and mitochondrial biogenesis. While there are limitations in studying metabolic flux in traditional cell lines, there are now novel cell lines and sophisticated tools available to study osteocyte bioenergetics to help harness its potential in vivo in the future.
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影响因子：
8.8
作者：
Kitase Y;Vallejo JA;Gutheil W;Vemula H;Jähn K;Yi J;Zhou J;Brotto M;Bonewald LF
通讯作者：
Bonewald LF
DOI：
10.1002/jbmr.3167
发表时间：
2017-08
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
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通讯作者：
Bonewald LF
影响因子：
8
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通讯作者：
Riddle, Ryan C.
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影响因子：
13.6
作者：
Gao, Junjie;Qin, An;Zheng, Ming H.
通讯作者：
Zheng, Ming H.
影响因子：
8.8
作者：
Lee WC;Ji X;Nissim I;Long F
通讯作者：
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