Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
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DOI：
10.1002/ajh.21760
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发表时间：
2010-08
影响因子：
12.8
通讯作者：
Lan, Qing
中科院分区：
文献类型：
--
作者：
Lee, Kyoung-Mu;Baris, Dalsu;Zhang, Yawei;Hosgood, H. Dean, III;Menashe, Idan;Yeager, Meredith;Zahm, Shelia Hoar;Wang, Sophia S.;Purdue, Mark P.;Chanock, Stephen;Zheng, Tongzhang;Rothman, Nathaniel;Lan, Qing
鉴于免疫系统失调与多发性骨髓瘤（MM）风险之间的关系，我们在一项基于人群的病例对照研究（康涅狄格州的白人女性，108例病例和482例对照）中，调查了77个基因区域中92个免疫功能基因的遗传变异是否与MM易感性相关。使用基于成对连锁不平衡的算法选择标签单核苷酸多态性（SNP；N = 870）。使用无条件逻辑回归估计SNP基因型的比值比（OR）和95%置信区间（CI）。使用minP检验对基因区域进行关联性检验。我们将错误发现率（FDR）方法应用于minP检验结果，作为控制多重比较的一种手段。位于12p13 - q13的CD4基因区域（minP = 0.0009），FDR值<0.1。在该区域，两个基因（CD4和LAG3）中的总共六个标签SNP与MM风险显著相关（趋势P<0.05），其中CD4变异体rs11064392的关联性最强（ORAG/GG = 2.53，95% CI = 1.59 - 4.02）。我们的研究结果表明，CD4的遗传变异可能影响对MM的易感性。需要更多的研究来重复这些发现，并且更广泛地探索基因受体可能影响这种了解甚少的恶性肿瘤发病机制的方式。
In light of the relationship between immune system dysregulation and multiple myeloma (MM) risk, we investigated whether genetic variation in 92 immune function genes among 77 gene regions are associated with MM susceptibility in a population-based case-control study (108 cases and 482 controls) conducted among Caucasian women in Connecticut. Tagging single-nucleotide polymorphisms (SNPs; N=870) were selected using a pairwise linkage-disequilibrium based algorithm. Odds ratios (ORs) and 95% confidence intervals (CIs) for SNP genotypes were estimated using unconditional logistic regression. Tests of association for gene regions were conducted using the minP test. We applied the false discovery rate (FDR) method to the minP test results as a means of controlling for multiple comparisons. The CD4 gene region located on 12p13-q13 (minP=0.0009), had an FDR value < 0.1. In this region, a total of six tag SNPs in two genes (CD4 and LAG3) were significantly associated with MM risk (Ptrend<0.05), with the strongest association observed for the CD4 variant rs11064392 (ORAG/GG=2.53, 95% CI=1.59–4.02). Our findings suggest that genetic variation in CD4 may influence susceptibility to MM. Additional studies are needed to replicate these findings and, more generally, to explore the manner in which genes receptors may influence the pathogenesis of this poorly understood malignancy.
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影响因子：
3.3
作者：
Lundmark, Frida;Harbo, Hanne F.;Hillert, Jan
通讯作者：
Hillert, Jan
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6.4
作者：
Oyugi, Julius O.;Vouriot, Francoise C. M.;Fowke, Keith R.
通讯作者：
Fowke, Keith R.
影响因子：
6.4
作者：
Brown, Elizabeth E.;Lan, Qing;Baris, Dalsu
通讯作者：
Baris, Dalsu
影响因子：
2.7
作者：
Ogawara, H;Handa, H;Murakami, H
通讯作者：
Murakami, H