The influence of aging on basal and secretin stimulated pancreatic exocrine secretion in the unanesthetized rat
The influence of aging on basal and secretin stimulated pancreatic exocrine secretion in the unanesthetized rat
复制标题
衰老对未麻醉大鼠基础和促胰液素刺激的胰腺外分泌的影响
作者：
D. Pelot;Julie V. LoRusso;D. Hollander
由于老年个体胰腺外分泌功能不全的临床报告，我们探讨了衰老对基础和促胰液素刺激的胰腺外分泌分泌的影响。我们研究了 3、4、13、24 和 27 个月大、意识清醒的大鼠，胰腺分泌物外引流、胆汁流动通畅、胃分泌物完全分流。测量胰液的体积，并测定碳酸氢盐、蛋白质含量和淀粉酶活性。老年动物（27个月大）的基础分泌量和刺激分泌量、碳酸氢盐输出、蛋白质输出和淀粉酶输出均急剧减少。因此，该动物模型中的衰老与外分泌胰腺分泌物的显着减少有关，这表明人类的孤立病例报告可能代表了比人们认识到的更常见的问题。
We explored the effect of aging on basal and secretin stimulated pancreatic exocrine secretion because of clinical reports of pancreatic exocrine insufficiency in aging individuals. We studied conscious rats, 3, 4, 13, 24 and 27 months of age, with external drainage of pancreatic secretions, unobstructed bile flow, and complete diversion of gastric secretions. Pancreatic juice was measured for volume, and assayed for bicarbonate, protein content, and amylase activity.Aged animals (27 months of age) had drastic reductions in both basal and stimulated secretory volume, bicarbonate output, protein output, and amylase output. Thus, aging in this animal model is associated with marked decrease in exocrine pancreatic secretions, suggesting that the isolated case reports in man may represent a more common problem than has been appreciated.
未麻醉大鼠中与衰老相关的胰腺外分泌功能不全。
影响因子：
3.5
作者：
Hollander,D;Dadufalza,VD
通讯作者：
Dadufalza,VD