Tracheal remodelling in response to hypoxia.
Tracheal remodelling in response to hypoxia.
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DOI：
10.1016/j.jinsphys.2009.05.008
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发表时间：
2010-05
影响因子：
2.2
通讯作者：
Wappner, Pablo
中科院分区：
文献类型：
--
作者：
Centanin, Lazaro;Gorr, Thomas A.;Wappner, Pablo
昆虫气管系统是一个连续的管状网络，分叉成逐渐变细的分支，直接向全身的每个器官和组织提供空气。在胚胎发生过程中，气管系统的基本结构以典型的和遗传控制的方式发育。后来，在幼虫阶段，气管系统变得可塑，并适应身体不同组织的特定氧气需求。氧感应由特定的脯氨酰 4 羟化酶介导，该酶调节 HIF 家族氧响应转录因子 α 亚基的蛋白质稳定性。气管细胞对氧气水平非常敏感，调节缺氧诱导蛋白的表达，介导气管分支向缺氧组织的方向发芽。
The insect tracheal system is a continuous tubular network that ramifies into progressively thinner branches to provide air directly to every organ and tissue throughout the body. During embryogenesis the basic architecture of the tracheal system develops in a stereotypical and genetically controlled manner. Later, in larval stages, the tracheal system becomes plastic, and adapts to particular oxygen needs of the different tissues of the body. Oxygen sensing is mediated by specific prolyl-4-hydroxylases that regulate protein stability of the alpha subunit of oxygen-responsive transcription factors from the HIF family. Tracheal cells are exquisitely sensitive to oxygen levels, modulating the expression of hypoxia-inducible proteins that mediate sprouting of tracheal branches in direction to oxygen-deprived tissues.
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