Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function.
Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function.
复制标题
DOI：
10.1016/j.trsl.2011.05.004
复制
发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Dulin N
中科院分区：
文献类型：
--
作者：
Sandbo N;Dulin N
肌成纤维细胞是修饰的成纤维细胞，其特征在于存在发育良好的收缩装置，并形成坚固的肌动蛋白应力纤维。这些机械活性细胞被认为在响应组织损伤的正常伤口愈合过程中以及在纤维化疾病中发现的异常组织重塑过程中协调细胞外基质重塑。本综述调查了对肌动蛋白应力纤维在肌成纤维细胞生物学中的作用的理解。从其最初被描述为定义的超微结构和形态学特征，到被广泛接受的观察结果证明其参与收缩、粘着斑成熟和细胞外基质重组，最后到最近的观察结果证明其在将机械力转换为生化信号、参与运动、收缩和基质重组的基因的转录控制以及局部化方面的作用。 mRNA翻译的调节。肌动蛋白应力纤维的这种广泛功能可通过诱导蛋白质表达来增强和放大其机械功能，这些蛋白质本身会增强收缩、粘着斑形成和基质重塑。在复合材料中，肌动蛋白细胞骨架的功能通常是对齐的，允许信号的整合和放大，促进纤维形成过程中的肌成纤维细胞分化和基质重塑。
Myofibroblasts are modified fibroblasts, characterized by the presence of a well-developed contractile apparatus, and the formation of robust actin stress fibers. These mechanically active cells are thought to orchestrate extracellular matrix remodeling during normal wound healing in response to tissue injury, and in aberrant tissue remodeling found in fibrosing disorders. This review surveys the understanding of the role of actin stress fibers in myofibroblast biology. From its original description as a defining ultrastructural and morphologic feature, to well-accepted observations demonstrating its participation in contraction, focal adhesion maturation, and extracellular matrix reorganization, and finally to more recent observations demonstrating its role in transducing mechanical force into biochemical signals, transcriptional control of genes involved in locomotion, contraction, and matrix reorganization, and the localized regulation of mRNA translation. This breadth of functionality of the actin stress fiber serves to reinforce and amplify its mechanical function, via induced expression of proteins that themselves augment contraction, focal adhesion formation, and matrix remodeling. In composite, the functions of the actin cytoskeleton are most often aligned, allowing for the integration and amplification of signals promoting both myofibroblast differentiation and matrix remodeling during fibrogenesis.
登录
查看更多内容
影响因子：
64.5
作者：
Choquet, D;Felsenfeld, DP;Sheetz, MP
通讯作者：
Sheetz, MP
影响因子：
3.5
作者：
BORSI, L;CASTELLANI, P;ZARDI, L
通讯作者：
ZARDI, L
影响因子：
16
作者：
Descot, Arnaud;Hoffmann, Reinhard;Posern, Guido
通讯作者：
Posern, Guido
影响因子：
6
作者：
Chambers, RC;Leoni, P;Heller, RA
通讯作者：
Heller, RA
影响因子：
64.8
作者：
Chicurel, ME;Singer, RH;Ingber, DE
通讯作者：
Ingber, DE