Hindlimb stretching alters locomotor function after spinal cord injury in the adult rat.
Hindlimb stretching alters locomotor function after spinal cord injury in the adult rat.
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DOI：
10.1177/1545968314543500
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发表时间：
2015-03
影响因子：
4.2
通讯作者：
Magnuson DS
中科院分区：
文献类型：
--
作者：
Caudle KL;Atkinson DA;Brown EH;Donaldson K;Seibt E;Chea T;Smith E;Chung K;Shum-Siu A;Cron CC;Magnuson DS
拉伸是脊髓损伤后被广泛接受的标准治疗方法，尚未在动物模型中进行系统研究。研究日常拉伸理疗对中度T9挫伤性脊髓损伤成年大鼠运动功能恢复的影响。急性脊髓损伤（SCI）动物模型中拉伸的随机治疗和对照研究。使用NYU打入器输送中度脊髓损伤。每日伸展（30分钟/每天，5天/周，持续8周）。采用BBB旷场运动量表和运动学评估后肢功能。每周使用测角器测定每个关节的被动活动范围。前4周观察到地上踏步时后肢功能下降。BBB评分在第5-10周有所改善，但仍低于对照组。从第4周开始，拉伸动物的膝关节被动ROM显著不足，并持续研究期间。运动学评估显示，在第5周开始部分恢复的踏步过程中关节偏移减少。基于拉伸的治疗显著损害了T10中度挫伤性SCI成年大鼠的功能恢复。对功能的负面影响是最大的急性，但持续即使在拉伸停止后8周受伤后。
Stretching is a widely accepted standard-of-care therapy following spinal cord injury that has not been systematically studied in animal models. To investigate the influence of a daily stretch-based physical therapy program on locomotor recovery in adult rats with moderate T9 contusive SCI. A randomized treatment and control study of stretching in an animal model of acute spinal cord injury (SCI). Moderate spinal cord injuries were delivered with the NYU Impactor. Daily stretching (30 min./day, 5 days/wk for 8 wks) was provided by a team of animal handlers. Hindlimb function was assessed using the BBB Open Field Locomotor Scale and kinematically. Passive range-of-motion for each joint was determined weekly using a goniometer. Declines in hindlimb function during overground stepping were observed for the first 4 weeks. BBB scores improved weeks 5–10 but remained below the control group. Stretched animals had significant deficits in knee passive ROM starting at week 4 and for the duration of the study. Kinematic assessment showed decreased joint excursion during stepping that partially recovered beginning at week 5. Stretch-based therapy significantly impaired functional recovery in adult rats with a moderate contusive SCI at T10. The negative impact on function was greatest acutely, but persisted even after the stretching ceased at 8 weeks post-injury.
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影响因子：
4.2
作者：
Magnuson DS;Smith RR;Brown EH;Enzmann G;Angeli C;Quesada PM;Burke D
通讯作者：
Burke D
DOI：
10.1111/j.1600-0838.2009.00926.x
发表时间：
2010-02-01
影响因子：
4.1
作者：
Ben, M.;Harvey, L. A.
通讯作者：
Harvey, L. A.
影响因子：
2
作者：
Harvey, Lisa A.;Glinsky, Joanne A.;Ben, Marsha
通讯作者：
Ben, Marsha
影响因子：
2.7
作者：
Segal, Richard L.;Lewek, Michael D.;Mercer, Vicki S.
通讯作者：
Mercer, Vicki S.
影响因子：
5.3
作者：
Kuerzi, J.;Brown, E. H.;Magnuson, D. S. K.
通讯作者：
Magnuson, D. S. K.