Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.
Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.
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DOI：
10.1016/j.bbamcr.2014.09.009
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发表时间：
2015-06
影响因子：
5.1
通讯作者：
Rouault, Tracey A.
中科院分区：
文献类型：
--
作者：
Maio, Nunziata;Rouault, Tracey A.
铁硫（Fe-S）团簇是由铁和无机硫组成的古老的、普遍存在的辅因子。铁和硫的化学反应性的组合，连同簇组成、氧化态和蛋白质环境的许多变化，使得Fe-S簇能够参与许多生物过程。Fe-S簇对于固氮、线粒体呼吸和光合作用中的氧化还原催化，对于关键代谢途径中的调节传感（即，e.细胞铁稳态和氧化应激反应），以及核基因组的复制和维持。Fe-S簇生物发生是一个多步骤的过程，其涉及催化蛋白质-蛋白质相互作用的复杂序列和几个专用多聚体复合物的组分之间的偶联构象变化。对组装过程的深入研究已经阐明了Fe-S蛋白生物发生的关键点。然而，一些关键问题仍然存在，如：什么是共济失调蛋白的作用？为什么Fe-S簇生物合成的某些缺陷会导致线粒体铁超载？在铁硫转运过程中，特异性铁硫受体蛋白是如何被识别的？本文综述了Fe-S簇生物发生的基本步骤，并对Cochaperone HSC 20指导新生Fe-S受体特定亚群选择的分子特征的鉴定方面取得的最新进展进行了综述。此外，它概述了人类疾病的独特表型，由于突变的基本途径的组成部分。
Iron-sulfur (Fe-S) clusters are ancient, ubiquitous cofactors composed of iron and inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with many variations of cluster composition, oxidation states and protein environments, enables Fe-S clusters to participate in numerous biological processes. Fe-S clusters are essential to redox catalysis in nitrogen fixation, mitochondrial respiration and photosynthesis, to regulatory sensing in key metabolic pathways (i. e. cellular iron homeostasis and oxidative stress response), and to the replication and maintenance of the nuclear genome. Fe-S cluster biogenesis is a multistep process that involves a complex sequence of catalyzed protein- protein interactions and coupled conformational changes between the components of several dedicated multimeric complexes. Intensive studies of the assembly process have clarified key points in the biogenesis of Fe-S proteins. However several critical questions still remain, such as: what is the role of frataxin? Why do some defects of Fe-S cluster biogenesis cause mitochondrial iron overload? How are specific Fe-S recipient proteins recognized in the process of Fe-S transfer? This review focuses on the basic steps of Fe-S cluster biogenesis, drawing attention to recent advances achieved on the identification of molecular features that guide selection of specific subsets of nascent Fe-S recipients by the cochaperone HSC20. Additionally, it outlines the distinctive phenotypes of human diseases due to mutations in the components of the basic pathway.
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影响因子：
5.3
作者：
Biederbick, Annette;Stehling, Oliver;Lill, Roland
通讯作者：
Lill, Roland
影响因子：
9.8
作者：
Bidichandani, SI;Ashizawa, T;Patel, PI
通讯作者：
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影响因子：
15.9
作者：
BONKOWSKY, HL;BLOOMER, JR;MAHONEY, MJ
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MAHONEY, MJ
影响因子：
11.4
作者：
ALDEA, M;GARRIDO, T;KUSHNER, SR
通讯作者：
KUSHNER, SR
DOI：
10.1073/pnas.1322438111
发表时间：
2014-04-08
影响因子：
11.1
作者：
Angerer, Heike;Radermacher, Michael;Zickermann, Volker
通讯作者：
Zickermann, Volker