Cardiopulmonary exercise pattern in patients with persistent dyspnoea after recovery from COVID-19.
Cardiopulmonary exercise pattern in patients with persistent dyspnoea after recovery from COVID-19.
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DOI：
10.4081/mrm.2021.732
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发表时间：
2021-01-15
影响因子：
2.3
通讯作者：
Koch M
中科院分区：
文献类型：
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作者：
Mohr A;Dannerbeck L;Lange TJ;Pfeifer M;Blaas S;Salzberger B;Hitzenbichler F;Koch M
COVID-19康复后持续呼吸困难的原因和机制尚未得到很好的描述。目的是描述COVID-19后患者持续呼吸困难的因果因素。我们通过心肺运动试验检查了COVID-19恢复后报告呼吸困难的患者。排除既存肺部疾病患者后，对2020年5月14日至9月15日期间的10例患者（平均年龄50±13.1岁）进行了回顾性分析。在胸部计算机断层扫描中，5例患者显示残留磨玻璃样阴影，1例患者显示条纹状残留。在队列中观察到肺的一氧化碳平均弥散量略有降低。平均峰值摄氧量降低为1512±232 ml/min（72.7%预测值），而平均峰值工作率保持为131±29 W（92.4%预测值）。运动峰值时的平均肺泡动脉氧分压差（AaDO 2）为25.6±11.8 mmHg。运动后乳酸的平均值为5.6±1.8 mmol/l。峰值工作率（92.4%预测值）与峰值摄氧量（72.3%预测值）之间的差距在我们的研究队列中检测到。在我们的研究人群中，运动后乳酸盐的平均值较高，甚至更高（n.s.）与峰值摄氧量降低和其他明显原因限制的患者亚组相比。这两个观察结果都支持无氧代谢的假说。因此，呼吸困难的主要原因可能是肌肉。
Cause and mechanisms of persistent dyspnoea after recovery from COVID-19 are not well described. The objective is to describe causal factors for persistent dyspnoea in patients after COVID-19. We examined patients reporting dyspnoea after recovery from COVID-19 by cardiopulmonary exercise testing. After exclusion of patients with pre-existing lung diseases, ten patients (mean age 50±13.1 years) were retrospectively analysed between May 14th and September 15th, 2020. On chest computed tomography, five patients showed residual ground glass opacities, and one patient showed streaky residua. A slight reduction of the mean diffusion capacity of the lung for carbon monoxide was noted in the cohort. Mean peak oxygen uptake was reduced with 1512±232 ml/min (72.7% predicted), while mean peak work rate was preserved with 131±29 W (92.4% predicted). Mean alveolar-arterial oxygen gradient (AaDO2) at peak exercise was 25.6±11.8 mmHg. Mean value of lactate post exercise was 5.6±1.8 mmol/l. A gap between peak work rate in (92.4% predicted) to peak oxygen uptake (72.3% pred.) was detected in our study cohort. Mean value of lactate post exercise was high in our study population and even higher (n.s.) compared to the subgroup of patients with reduced peak oxygen uptake and other obvious reason for limitation. Both observations support the hypothesis of anaerobic metabolism. The main reason for dyspnoea may therefore be muscular.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
影响因子：
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作者：
Orsucci, Daniele;Ienco, Elena Caldarazzo;Vista, Marco
通讯作者：
Vista, Marco
影响因子：
168.9
作者：
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通讯作者：
Cao, Bin
影响因子：
8.1
作者：
Brandstetter, Susanne;Dodoo-Schittko, Frank;Apfelbacher, Christian
通讯作者：
Apfelbacher, Christian
影响因子：
5.8
作者：
通讯作者：
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