Fecal immunochemical test (FIT) versus colonoscopy: Does knowing that a positive FIT requires a follow-up colonoscopy affect initial decision making in the US?
Fecal immunochemical test (FIT) versus colonoscopy: Does knowing that a positive FIT requires a follow-up colonoscopy affect initial decision making in the US?
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DOI：
10.1016/j.pmedr.2022.101825
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发表时间：
2022-06
影响因子：
2.8
通讯作者：
Almario, Christopher, V
中科院分区：
文献类型：
--
作者：
Shergill, Jaspreet;Makaroff, Katherine E.;Lauzon, Marie;Spiegel, Brennan M. R.;Almario, Christopher, V
尽管许多人更喜欢粪便免疫化学试验（FIT）而不是结肠镜检查，因为它的无创性，但如果他们明确告知+ FIT需要随访结肠镜检查，FIT是否仍然是结直肠癌（CRC）筛查的首选，目前尚不清楚。为了解决这一差距，我们对美国全国范围内的美国人样本进行了两项联合分析调查，其中一项调查解释了+ FIT后是否需要随访结肠镜检查，而另一项则没有，然后评估了在队列之间结肠镜检查/FIT偏好是否存在差异。我们招募了≥40岁、未通过在线调查研究公司接受过结直肠癌筛查的成年人。我们部署了两项调查，使用联合分析来评估围绕CRC筛查试验的决策：调查1(4/2-4/15/2021)-没有告知参与者在FIT +后需要结肠镜检查；调查2(4/29-6/2/2021)-告知受访者潜在需求。使用联合分析数据，我们确定了首选FIT或结肠镜检查的患者比例，然后使用逻辑回归来评估队列之间结肠镜检查/FIT偏好的差异。总体而言，分别有501人和1000人完成了调查1（没有描述FIT +后结肠镜检查的需要）和调查2（有描述）。在logistic回归中调整协变量后，队列间的检验偏好无差异（调整p = 0.09）：调查1（未描述）-结肠镜检查28.5%,FIT 71.5%；调查2（含描述）-结肠镜检查26.7%,FIT 73.3%。因此，知道a + FIT需要后续结肠镜检查并不能改变人们对非侵入性粪便测试FIT的强烈偏好。
Although many people prefer fecal immunochemical test (FIT) over colonoscopy due to its noninvasive nature, it is unclear whether FIT would still be preferred for colorectal cancer (CRC) screening if they were explicitly informed that + FIT requires follow-up colonoscopy. To address this gap, we administered two conjoint analysis surveys—one that explained the need for a follow-up colonoscopy after + FIT while the other did not—to a US nationwide sample of Americans and then assessed whether there were differences in colonoscopy/FIT preferences between cohorts. We recruited adults ≥ 40yo who had not undergone CRC screening via an online survey research firm. We deployed two surveys that used conjoint analysis to assess decision making surrounding CRC screening tests: Survey 1 (4/2–4/15/2021)—did not inform participants that they need a colonoscopy following a + FIT; Survey 2 (4/29–6/2/2021)—informed respondents of the potential need. Using the conjoint analysis data, we determined the proportion of those who preferred FIT or colonoscopy and then used logistic regression to assess for differences in colonoscopy/FIT preferences between the cohorts. Overall, 501 and 1,000 individuals completed Survey 1 (without description of need for colonoscopy after + FIT) and Survey 2 (with description), respectively. There was no difference in test preference between cohorts after adjusting for covariates in the logistic regression (adjusted p = 0.09): Survey 1 (without description)—colonoscopy 28.5%, FIT 71.5%; Survey 2 (with description)—colonoscopy 26.7%, FIT 73.3%. Thus, knowledge that a + FIT requires a follow-up colonoscopy does not alter people’s strong preference for non-invasive stool testing with FIT.
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