The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.
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作者：
白细胞介素23（IL-23）是由辅助性T细胞17型（TH-17细胞）介导的自身免疫炎症所必需的，并且与许多人类免疫疾病有关。在此，我们将IL-23受体（IL-23 R）缺陷限制在体内确定的细胞群中，以研究TH-17发育和自身免疫、炎症和感染中功能对IL-23信号传导的需求。在没有IL-23的情况下，TH-17发育在早期活化阶段“停滞”。TH-17细胞不能下调IL-2和肿瘤坏死因子受体超家族成员CD 27，维持IL-17的产生并上调IL-7 R α的表达。这些缺陷与增殖减少和离开淋巴结进入血流和组织的效应TH-17细胞数量减少有关。
Interleukin 23 (IL-23) is required for autoimmune inflammation mediated by T helper type 17 cells (TH-17 cells) and is implicated in a number of human immune disorders. Here we restricted IL-23 receptor (IL-23R) deficiency to defined cell populations in vivo to investigate the requirement for IL-23 signaling in TH-17 development and function in autoimmunity, inflammation, and infection. In the absence of IL-23, TH-17 development was ‘stalled’ at the early activation stage. TH-17 cells failed to downregulate IL-2 and the tumor necrosis factor receptor superfamily member CD27, to maintain IL-17 production and to upregulate IL-7Rα expression. These defects were associated with reduced proliferation and reduced numbers of effector TH-17 cells that exit lymph nodes destined for the bloodstream and tissues.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
DOI：
10.1084/jem.20030735
发表时间：
2003-12-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kondrack RM;Harbertson J;Tan JT;McBreen ME;Surh CD;Bradley LM
通讯作者：
Bradley LM
影响因子：
56.9
作者：
Duerr, Richard H.;Taylor, Kent D.;Cho, Judy H.
通讯作者：
Cho, Judy H.
影响因子：
4.4
作者：
Mathur, Anubhav N.;Chang, Hua-Chen;Kaplan, Mark H.
通讯作者：
Kaplan, Mark H.