Interleukin 7 regulates the survival and generation of memory CD4 cells.
Interleukin 7 regulates the survival and generation of memory CD4 cells.
复制标题
DOI：
10.1084/jem.20030735
复制
发表时间：
2003-12-15
期刊：
影响因子：
--
通讯作者：
Bradley LM
中科院分区：
文献类型：
--
作者：
Kondrack RM;Harbertson J;Tan JT;McBreen ME;Surh CD;Bradley LM
细胞因子，特别是常见γ链受体家族的细胞因子，提供调节初始CD 4细胞存活的外源性信号。这些细胞因子是否是维持记忆性CD 4细胞所必需的尚未得到严格评估。在本文中，我们研究了白细胞介素（IL）7，一个组成性产生的共同γ链受体细胞因子，对静息T细胞受体转基因记忆CD 4细胞的存活的贡献，在体内产生。IL-7介导的存活和上调Bcl-2的静息记忆CD 4细胞在体外的情况下，增殖。记忆性CD 4细胞在过继转移到完整或淋巴细胞减少的受体后持续较长时间，但在IL-7−小鼠或通过抗体阻断导致IL-7缺乏的受体中则不然。中枢（CD 62 L+）和效应（CD 62 L-）记忆表型CD 4细胞都需要IL-7才能存活，在体内，记忆细胞在这方面与初始CD 4细胞相当。虽然产生初级效应细胞从幼稚的CD 4细胞和他们的传播到非淋巴组织不受IL-7缺乏症，记忆细胞未能随后开发的淋巴或非淋巴车厢。结果表明，IL-7在维持CD 4细胞群的记忆和具有成为记忆细胞能力的CD 4细胞的存活中具有先前未被认识到的作用。
Cytokines, particularly those of the common γ chain receptor family, provide extrinsic signals that regulate naive CD4 cell survival. Whether these cytokines are required for the maintenance of memory CD4 cells has not been rigorously assessed. In this paper, we examined the contribution of interleukin (IL) 7, a constitutively produced common γ chain receptor cytokine, to the survival of resting T cell receptor transgenic memory CD4 cells that were generated in vivo. IL-7 mediated the survival and up-regulation of Bcl-2 by resting memory CD4 cells in vitro in the absence of proliferation. Memory CD4 cells persisted for extended periods upon adoptive transfer into intact or lymphopenic recipients, but not in IL-7− mice or in recipients that were rendered deficient in IL-7 by antibody blocking. Both central (CD62L+) and effector (CD62L−) memory phenotype CD4 cells required IL-7 for survival and, in vivo, memory cells were comparable to naive CD4 cells in this regard. Although the generation of primary effector cells from naive CD4 cells and their dissemination to nonlymphoid tissues were not affected by IL-7 deficiency, memory cells failed to subsequently develop in either the lymphoid or nonlymphoid compartments. The results demonstrate that IL-7 can have previously unrecognized roles in the maintenance of memory in the CD4 cell population and in the survival of CD4 cells with a capacity to become memory cells.
登录
查看更多内容
影响因子：
32.4
作者：
Ernst, B;Lee, DS;Surh, CD
通讯作者：
Surh, CD
人类天真，中央记忆和效应记忆CD4（+）T细胞的细胞因子驱动的增殖和分化。
影响因子：
15.3
作者：
Geginat, J;Sallusto, F;Lanzavecchia, A
通讯作者：
Lanzavecchia, A
影响因子：
15.3
作者：
Goldrath, Ananda W;Sivakumar, Pallavur V;Glaccum, Moira;Kennedy, Mary K;Bevan, Michael J;Benoist, Christophe;Mathis, Diane;Butz, Eric A
通讯作者：
Butz, Eric A
影响因子：
30.5
作者：
Lantz, O;Grandjean, I;Di Santo, JP
通讯作者：
Di Santo, JP
DOI：
10.1084/jem.193.8.987
发表时间：
2001-04-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Iezzi G;Scheidegger D;Lanzavecchia A
通讯作者：
Lanzavecchia A