Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video).
Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video).
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DOI：
10.1016/j.gie.2018.07.009
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发表时间：
2018-11
影响因子：
7.7
通讯作者：
Tearney GJ
中科院分区：
文献类型：
--
作者：
Gora MJ;Quénéhervé L;Carruth RW;Lu W;Rosenberg M;Sauk JS;Fasano A;Lauwers GY;Nishioka NS;Tearney GJ
Patients with many different digestive diseases undergo repeated esophagogastroduodenoscopy throughout their life. Tethered capsule endomicroscopy (TCE) is a less invasive method for obtaining high-resolution images of the gastrointestinal mucosa for diagnosis and treatment planning of diseases. In this paper, we present our results from a single center, aimed at testing the safety and the feasibility of TCE for imaging the esophagus, stomach, and duodenum. After swallowed by an unsedated subject, the tethered capsule obtains cross-sectional 10-μm-resolution optical coherence tomography images as the device traverses the alimentary tract. Following imaging, the device is withdrawn through the mouth, disinfected, and reused. Safety and feasibility of TCE were tested, focusing on imaging the esophagus of healthy volunteers and patients with Barrett’s esophagus, and duodenum of healthy volunteers. Images were compared to endoscopy and histopathology findings when available. Thirty-eight patients were enrolled. No adverse effects were reported. TCE device swallowing rate was 34/38 (89%). The appearance of physiologic upper gastrointestinal wall, including its microscopic pathology was visualized in esophagus of BE subjects with and without endoscopic evidence of hiatal hernia, as well as in duodenum with a tissue coverage of 85.4 % ± 14.9 %, 90.3 % ± 6.8 % and 84.8% ± 7.4% respectively. A blinded comparison of TCE and endoscopic BE measurements showed a strong to very strong correlation (r = 0.7–0.83; p<0.05) for circumferential extent and a strong correlation (r=0.77–0.78; p< 0.01) for maximum extent (Prague classification). TCE interobserver correlation was very strong, r=0.92 and r=0.84 (p<0.01), for C and M measurements respectively. TCE is a safe and feasible procedure for obtaining high-resolution microscopic images of the upper GI tract without endoscopic assistance or sedation.
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影响因子：
82.9
作者：
通讯作者：
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影响因子：
3.5
作者：
Bredenoord, A. J.;Hebbard, G. S.
通讯作者：
Hebbard, G. S.
影响因子：
7.7
作者：
Suter, Melissa J.;Vakoc, Benjamin J.;Yachimski, Patrick S.;Shishkov, Milen;Lauwers, Gregory Y.;Mino-Kenudson, Mari;Bouma, Brett E.;Nishioka, Norman S.;Tearney, Guillermo J.
通讯作者：
Tearney, Guillermo J.
影响因子：
7.7
作者：
Isenberg, G;Sivak, MV;Rollins, A
通讯作者：
Rollins, A
影响因子：
7.7
作者：
Suter MJ;Gora MJ;Lauwers GY;Arnason T;Sauk J;Gallagher KA;Kava L;Tan KM;Soomro AR;Gallagher TP;Gardecki JA;Bouma BE;Rosenberg M;Nishioka NS;Tearney GJ
通讯作者：
Tearney GJ