Evaluation of Topology Optimization Using 3D Printing for Bioresorbable Fusion Cages: A Biomechanical Study in a Porcine Model.
Evaluation of Topology Optimization Using 3D Printing for Bioresorbable Fusion Cages: A Biomechanical Study in a Porcine Model.
复制标题
使用 3D 打印对生物可吸收融合笼的拓扑优化进行评估：猪模型的生物力学研究。
作者：
使用猪模型对生物可吸收聚己内酯（PCL）颈椎融合器进行拓扑优化与标准环设计的临床前生物力学研究，以输送骨形态发生蛋白-2（BMP-2）。目的是评价活动度（ROM）和骨融合，作为拓扑优化和BMP-2输送方法的函数。3D打印技术可以使用生物可吸收材料制造拓扑优化的融合器，提供多种优势，包括定制和较低的刚度。使用拓扑优化的BMP-2的递送可以提高融合的质量。22只6个月大的猪使用3D打印的PCL融合器在一个节段进行颈椎前路椎间盘切除融合。实验组（每组N=6）包括：第1组：具有表面吸附的BMP-2的环形设计，第2组：具有表面吸附的BMP-2的拓扑优化的矩形设计，以及第3组：具有通过胶原海绵递送的BMP-2的环形设计。另外的样本，每种设计两个，作为对照，在没有BMP-2的情况下植入。术后6个月取完整的颈椎节段。进行纳米计算机断层扫描以评估完整的骨桥接。分别在所有三个平面上进行纯力矩生物力学测试。记录并分析连续的3D运动。3例受试者出现早期手术并发症，未进行评价。总体而言，无论设计或BMP-2输送方法如何，实验样本的ROM都相当，组间无临床显著差异。在融合节段的实验样本中，屈曲和伸展ROM <1.0°，表明融合，基于临床应用的融合标准<2至4°。尽管测量了生物力学稳定性，但使用计算机断层扫描评价，在第1组40%的样本、第2组50%的样本、第3组100%的样本中观察到完全骨桥接，对照样本中无一例。拓扑优化的含BMP-2的PCL融合器能够实现椎间融合，类似于相同生物可吸收材料的传统环基设计。
Preclinical biomechanical study of topology optimization versus standard ring design for bioresorbable poly-ε-caprolactone (PCL) cervical spine fusion cages delivering bone morphogenetic protein-2 (BMP-2) using a porcine model. The aim was to evaluate range of motion (ROM) and bone fusion, as a function of topology optimization and BMP-2 delivery method. 3D printing technology enables fabrication of topology-optimized cages using bioresorbable materials, offering several advantages including customization, and lower stiffness. Delivery of BMP-2 using topology optimization may enhance the quality of fusion. Twenty-two 6-month-old pigs underwent anterior cervical discectomy fusion at one level using 3D printed PCL cages. Experimental groups (N=6 each) included: Group 1: ring design with surface adsorbed BMP-2, Group 2: topology-optimized rectangular design with surface adsorbed BMP-2, and Group 3: ring design with BMP-2 delivery via collagen sponge. Additional specimens, two of each design, were implanted without BMP-2, as controls. Complete cervical segments were harvested six months postoperatively. Nanocomputed tomography was performed to assess complete bony bridging. Pure moment biomechanical testing was conducted in all three planes, separately. Continuous 3D motions were recorded and analyzed. Three subjects suffered early surgical complications and were not evaluated. Overall, ROM for experimental specimens, regardless of design or BMP-2 delivery method, was comparable, with no clinically significant differences among groups. Among experimental specimens at the level of the fusion, ROM was <1.0° in flexion and extension, indicative of fusion, based on clinically applied criteria for fusion of <2 to 4°. Despite the measured biomechanical stability, using computed tomography evaluation, complete bony bridging was observed in 40% of the specimens in Group 1, 50% of Group 2, 100% of Group 3, and none of the control specimens. A topology-optimized PCL cage with BMP-2 is capable of resulting in an intervertebral fusion, similar to a conventional ring-based design of the same bioresorbable material.
DOI：
10.5402/2012/452703
发表时间：
2012
期刊：
ISRN neurology
影响因子：
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作者：
Liu H;Ploumis A;Li C;Yi X;Li H
通讯作者：
Li H
影响因子：
--
作者：
Daentzer D;Floerkemeier T;Bartsch I;Masalha W;Welke B;Hurschler C;Kauth T;Kaltbeitzel D;Hopmann C;Kujat B;Kalla K
通讯作者：
Kalla K