Molecular characterization of an uncommon multigene Reassortant G1P[4] rotavirus identified in China.
Molecular characterization of an uncommon multigene Reassortant G1P[4] rotavirus identified in China.
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中国发现的罕见多基因重配 G1P[4] 轮状病毒的分子特征。
DOI：
10.1016/j.meegid.2020.104413
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
N. Xia
中科院分区：
文献类型：
--
作者：
Yuanjun Zeng;Biyan Zhao;Tingdong Li;Shiyin Zhang;Yingbin Wang;Hongmei Xu;S. Ge;N. Xia
轮状病毒A （RVA）是全球幼儿和动物急性胃肠炎的主要原因。在这项研究中，我们分析了一种罕见的G1P[4]轮状病毒的全基因组序列，该病毒是从中国重庆一名腹泻婴儿的粪便样本（20130113）中鉴定出来的。菌株20130113的基因型星座为G1-P[4]-I2-R1-C1-M1-A2-N2-T1-E1-H1。BLAST和系统发育分析结果表明，20130113可能是由G1P[8]和G2P[4]菌株在季节共同传播的基因重组产生的。这种不常见基因型的出现是否反映了在人群中建立了新的RVA毒株，需要对轮状病毒流行病学进行持续监测。
Rotavirus A (RVA) is the leading cause of acute gastroenteritis worldwide in both young children and animals. In this study, we analyzed the complete genome sequence of a rare G1P[4] rotavirus, which was identified from the stool samples (20130113) of an infant with diarrhea in Chongqing, China. The genotype constellation of strain 20130113 was G1-P[4]-I2-R1-C1-M1-A2-N2-T1-E1-H1. The results of both BLAST and phylogenic analysis indicated that 20130113 was likely generated by genetic reassortment between G1P[8] and G2P[4] strains that co-circulated during the season. Whether the emergence of this uncommon genotype reflects the establishment of a new RVA strain in the population requires continuous monitoring of rotavirus epidemiology.
使用所有11个基因组RNA片段的轮状病毒组分类的建议。
影响因子：
2.7
作者：
Matthijnssens, Jelle;Ciarlet, Max;Rahman, Mustafizur;Attoui, Houssam;Banyai, Krisztian;Estes, Mary K.;Gentsch, Jon R.;Iturriza-Gomara, Miren;Kirkwood, Carl D.;Martella, Vito;Mertens, Peter P. C.;Nakagomi, Osamu;Patton, John T.;Ruggeri, Franco M.;Saif, Linda J.;Santos, Norma;Steyer, Andrej;Taniguchi, Koki;Desselberger, Ulrich;Van Ranst, Marc
通讯作者：
Van Ranst, Marc