T cell-mediated hypersensitivity reactions to drugs.
T cell-mediated hypersensitivity reactions to drugs.
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DOI：
10.1146/annurev-med-050913-022745
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发表时间：
2015
影响因子：
10.5
通讯作者：
Phillips E
中科院分区：
文献类型：
--
作者：
Pavlos R;Mallal S;Ostrov D;Buus S;Metushi I;Peters B;Phillips E
通过几个关键实例及其人类白细胞抗原（HLA）相关性举例说明了药物反应性T淋巴细胞介导的药物迟发性超敏反应（HSR）的免疫学机制：阿巴卡韦和HLA-B*57：01、卡马西平和HLA-B*15：02、别嘌呤醇和HLA-B*58：01以及具有多个I类和II类等位基因的阿莫西林-克拉维汀和奈韦拉平。对于HLA限制性药物HSR，特异性I类和/或II类HLA等位基因是必要的，但对于组织特异性和临床综合征是不够的。已经提出了几种模型来解释严重的T细胞介导的药物HSR的免疫发病机制，我们对这些反应发展中涉及的风险因素和机制的了解将进一步发展敏感和特异性的临床前筛选策略，从而导致更安全和更具成本效益的药物设计。
The immunological mechanisms driving delayed hypersensitivity reactions (HSRs) to drugs mediated by drug-reactive T lymphocytes are exemplified by several key examples and their human leukocyte antigen (HLA) associations: abacavir and HLA-B*57:01, carbamazepine and HLA-B*15:02, allopurinol and HLA-B*58:01, and both amoxicillin-clavulanate and nevirapine with multiple class I and II alleles. For HLA-restricted drug HSRs, specific class I and/or II HLA alleles are necessary but not sufficient for tissue specificity and the clinical syndrome. Several models have been proposed to explain the immunopathogenesis of severe T cell–mediated drug HSRs, and our increased understanding of the risk factors and mechanisms involved in the development of these reactions will further the development of sensitive and specific strategies for preclinical screening that will lead to safer and more cost-effective drug design.
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DOI：
10.1093/cid/cit021
发表时间：
2013-05
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Carr DF;Chaponda M;Jorgensen AL;Castro EC;van Oosterhout JJ;Khoo SH;Lalloo DG;Heyderman RS;Alfirevic A;Pirmohamed M
通讯作者：
Pirmohamed M
影响因子：
6.2
作者：
D'Orsogna, Lloyd J. A.;Roelen, Dave L.;Claas, Frans H. J.
通讯作者：
Claas, Frans H. J.
影响因子：
20.3
作者：
Amir, Avital L.;D'Orsogna, Lloyd J. A.;Heemskerk, Mirjam H. M.
通讯作者：
Heemskerk, Mirjam H. M.
影响因子：
6.2
作者：
Gamadia, LE;Remmerswaal, EB;Ten Berge, IJM
通讯作者：
Ten Berge, IJM
影响因子：
2.8
作者：
Genin, E.;Chen, D-P;Roujeau, J-C
通讯作者：
Roujeau, J-C