Health-related quality of life in acute heart failure: association between patient-reported symptoms and markers of congestion.
Health-related quality of life in acute heart failure: association between patient-reported symptoms and markers of congestion.
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DOI：
10.1002/ejhf.2699
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发表时间：
2023-01
影响因子：
18.2
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究旨在探讨急性心力衰竭（AHF）患者自述症状与肺淤血程度之间的关联。
在这项前瞻性观察研究中，对因AHF住院的患者，在基线时使用堪萨斯城心肌病问卷总症状评分（KCCQ - TSS）（范围0 - 100；0为最差）评估患者自述症状。在一个亚组中，在基线时检查患者自述的静息和活动时的呼吸困难（范围0 - 10；10为最差）。此外，在进行超声心动图检查时，在基线时进行4区肺部超声（LUS）检查。由一个核心实验室在不了解临床结果的情况下离线量化B线。从病历中收集胸部X线（CXR）和体格检查结果。在322例AHF患者（平均年龄72岁，60%为男性，平均左心室射血分数39%）中，KCCQ - TSS评分中位数为33（四分位间距18 - 48）。KCCQ - TSS评分越差，纽约心脏协会（NYHA）心功能分级越差，静息和活动时呼吸困难以及外周水肿越严重（所有指标p趋势<0.001）。然而，KCCQ - TSS与肺淤血程度无关，无论是通过LUS上的B线数量、CXR结果还是体格检查来评估（所有指标p趋势>0.25）。同样，KCCQ - TSS与左心室充盈压、肺动脉压的超声心动图指标以及N末端B型利钠肽原水平也无显著关联。
在因AHF住院的患者中，在基线时，KCCQ - TSS与通过LUS、CXR或体格检查评估的肺淤血无关。这些发现表明，AHF患者KCCQ - TSS的显著降低可能不能仅仅用肺淤血来解释。
患者自述症状与淤血标志物之间的关联。AHF，急性心力衰竭；IVC，下腔静脉；JVD，颈静脉怒张；KCCQ - TSS，堪萨斯城心肌病问卷总症状评分；NRS，数字评分量表；NT - proBNP，N末端B型利钠肽原；TR，三尖瓣反流
The aim of this study was to examine the association between patient-reported symptoms and the extent of pulmonary congestion in acute heart failure (AHF). In this prospective, observational study, patient-reported symptoms were assessed at baseline using the Kansas City Cardiomyopathy Questionnaire total symptom score (KCCQ-TSS) (range 0–100; 0 worst) in patients hospitalized for AHF. In a subset, patient-reported dyspnoea at rest and on exertion was examined (range 0–10; 10 worst) at baseline. In addition, 4-zone lung ultrasound (LUS) was performed at baseline at the time of echocardiography. B-lines were quantified offline, blinded to clinical findings, by a core laboratory. Chest X-ray (CXR) and physical examination findings were collected from the medical records. Among 322 patients (mean age 72, 60% men, mean left ventricular ejection fraction 39%) with AHF, the median KCCQ-TSS score was 33 (interquartile range 18–48). Worse KCCQ-TSS was associated with worse New York Heart Association class, dyspnoea at rest and on exertion, and peripheral oedema (p trend <0.001 for all). However, KCCQ-TSS was not associated with the extent of pulmonary congestion, as assessed by the number of B-lines on LUS, or findings on CXR, or physical examination (p trend >0.25 for all). Similarly, KCCQ-TSS was not significantly associated with echocardiographic markers of left ventricular filling pressure, pulmonary pressure or with N-terminal pro-B-type natriuretic peptide level. Among patients hospitalized for AHF, at baseline, KCCQ-TSS was not associated with pulmonary congestion assessed by LUS, CXR, or physical examination. These findings suggest that the profound reduction in KCCQ-TSS in patients with AHF may not be solely explained by pulmonary congestion. Association between patient-reported symptoms and markers of congestion. AHF, acute heart failure; IVC, inferior vena cava; JVD, jugular venous distention; KCCQ-TSS, Kansas City Cardiomyopathy Questionnaire total symptom score; NRS, numeric rating scale; NT-proBNP, N-terminal pro-B-type natriuretic peptide; TR, tricuspid regurgitation.
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影响因子：
39.3
作者：
Platz, Elke;Lewis, Eldrin F.;Solomon, Scott D.
通讯作者：
Solomon, Scott D.
DOI：
10.1016/j.jchf.2019.07.008
发表时间：
2019-10
期刊：
JACC. Heart failure
影响因子：
--
作者：
Platz E;Campbell RT;Claggett B;Lewis EF;Groarke JD;Docherty KF;Lee MMY;Merz AA;Silverman M;Swamy V;Lindner M;Rivero J;Solomon SD;McMurray JJV
通讯作者：
McMurray JJV
影响因子：
6
作者：
Sauser, Kori;Spertus, John A.;Pang, Peter S.
通讯作者：
Pang, Peter S.
DOI：
10.1016/s0735-1097(00)00531-3
发表时间：
2000-04-01
影响因子：
24
作者：
Green, CP;Porter, CB;Spertus, JA
通讯作者：
Spertus, JA
影响因子：
2
作者：
CUZICK, J
通讯作者：
CUZICK, J