Toward an optimal global stem cell donor recruitment strategy.
Toward an optimal global stem cell donor recruitment strategy.
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DOI：
10.1371/journal.pone.0086605
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Ehninger G
中科院分区：
文献类型：
--
作者：
Schmidt AH;Sauter J;Pingel J;Ehninger G
特定人群的匹配概率(MP)是评估无关干细胞捐赠者登记的好处和进一步招募捐赠者努力的必要性的关键参数。在这项研究中，我们描述了在考虑国际干细胞捐赠者交换的情况下，特定和混合患者群体的MP估计的一般框架。计算基于多达21个群体的群体特异性4个基因座(HLA-A、-B、-C、-DRB1)高分辨率单倍型频率(HF)。在不同的情况下，我们计算了几个高度实际相关性的数量，包括通过招募固定数量的捐赠者可以达到的最大MP，相应的按新登记人数划分的最优构成，以及需要招募的最小捐赠者数量才能达到定义的MP。从目前的捐献者人数开始，由于n = 增加了500,000名相同人口的捐赠者，来自波斯尼亚-黑塞哥维那(+0.25)、希腊(+0.21)和罗马尼亚(+0.20)的患者的MP增幅最大。特别是欧洲裔美国人(+0.004)、德国人(+0.01)和西班牙裔美国人(+0.01)的MP小幅增加。由于中国人口众多，n = 全球500万新捐献者的最佳分布包括390万中国捐赠者。作为我们计算的总体结果，我们观察到有必要招募相同人口的捐赠者，以便有效地增加特定人口的MP。这一结果是稳健的，尽管我们的输入数据存在局限性，包括使用了从n = 1028(波斯尼亚-黑塞哥维那)到n = 33,083(土耳其)相对较小的样本中提取的HF。因此，应严格重新评估忽视国内捐助者招募的国家战略，特别是在迄今只招募了少数捐助者的情况下。
Population-specific matching probabilities (MP) are a key parameter to assess the benefits of unrelated stem cell donor registries and the need for further donor recruitment efforts. In this study, we describe a general framework for MP estimations of specific and mixed patient populations under consideration of international stem cell donor exchange. Calculations were based on population-specific 4-locus (HLA-A, -B, -C, -DRB1) high-resolution haplotype frequencies (HF) of up to 21 populations. In various scenarios, we calculated several quantities of high practical relevance, including the maximal MP that can be reached by recruiting a fixed number of donors, the corresponding optimal composition by population of new registrants, and the minimal number of donors who need to be recruited to reach a defined MP. Starting at current donor numbers, the largest MP increases due to n = 500,000 additional same-population donors were observed for patients from Bosnia-Herzegovina (+0.25), Greece (+0.21) and Romania (+0.20). Especially small MP increases occurred for European Americans (+0.004), Germans (+0.01) and Hispanic Americans (+0.01). Due to the large Chinese population, the optimal distribution of n = 5,000,000 new donors worldwide included 3.9 million Chinese donors. As a general result of our calculations, we observed a need for same-population donor recruitment in order to increase population-specific MP efficiently. This result was robust despite limitations of our input data, including the use of HF derived from relatively small samples ranging from n = 1028 (Bosnia-Herzegovina) to n = 33,083 (Turkey) individuals. National strategies that neglect domestic donor recruitment should therefore be critically re-assessed, especially if only few donors have been recruited so far.
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通讯作者：
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