Intraflagellar Transport Proteins as Regulators of Primary Cilia Length.
Intraflagellar Transport Proteins as Regulators of Primary Cilia Length.
复制标题
DOI：
10.3389/fcell.2021.661350
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Tran PV
中科院分区：
文献类型：
--
作者：
Wang W;Jack BM;Wang HH;Kavanaugh MA;Maser RL;Tran PV
初级纤毛是小的，触角状的细胞器，其检测和识别细胞外环境中的化学和机械线索，调节细胞行为，进而调节组织发育和稳态。初级纤毛通过鞭毛内转运（IFT）组装，其沿着微管轴丝双向沿着运输蛋白质货物。这些细胞器的长度从1到10 μm不等，通常会根据细胞类型达到特定的长度，可能是为了最佳地履行其特定的角色。最佳纤毛长度的重要性是强调了纤毛长度的扰动，可以观察到在一些纤毛相关的疾病的发现。因此，阐明纤毛长度调节机制对于了解纤毛疾病的病理生物学非常重要。由于纤毛组装/拆卸调节纤毛长度，我们审查的作用，影响纤毛组装/拆卸的过程中，包括纤毛运输的结构和膜蛋白，胞吞作用，微管蛋白的翻译后修饰的IFT。此外，由于细胞的环境影响纤毛长度，我们还审查了各种刺激肾上皮细胞在健康和患病状态，改变纤毛长度和IFT。
Primary cilia are small, antenna-like organelles that detect and transduce chemical and mechanical cues in the extracellular environment, regulating cell behavior and, in turn, tissue development and homeostasis. Primary cilia are assembled via intraflagellar transport (IFT), which traffics protein cargo bidirectionally along a microtubular axoneme. Ranging from 1 to 10 μm long, these organelles typically reach a characteristic length dependent on cell type, likely for optimum fulfillment of their specific roles. The importance of an optimal cilia length is underscored by the findings that perturbation of cilia length can be observed in a number of cilia-related diseases. Thus, elucidating mechanisms of cilia length regulation is important for understanding the pathobiology of ciliary diseases. Since cilia assembly/disassembly regulate cilia length, we review the roles of IFT in processes that affect cilia assembly/disassembly, including ciliary transport of structural and membrane proteins, ectocytosis, and tubulin posttranslational modification. Additionally, since the environment of a cell influences cilia length, we also review the various stimuli encountered by renal epithelia in healthy and diseased states that alter cilia length and IFT.
登录
查看更多内容
DOI：
10.1161/hypertensionaha.111.172080
发表时间：
2011-08
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Abdul-Majeed S;Nauli SM
通讯作者：
Nauli SM
影响因子：
2
作者：
Alazami, Anas M;Seidahmed, Mohammed Zain;Alzahrani, Fatema;Mohammed, Adam O;Alkuraya, Fowzan S
通讯作者：
Alkuraya, Fowzan S
DOI：
10.1083/jcb.141.4.993
发表时间：
1998-05-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cole DG;Diener DR;Himelblau AL;Beech PL;Fuster JC;Rosenbaum JL
通讯作者：
Rosenbaum JL
影响因子：
2.7
作者：
Berbari NF;Kin NW;Sharma N;Michaud EJ;Kesterson RA;Yoder BK
通讯作者：
Yoder BK
影响因子：
9.2
作者：
Deane, JA;Cole, DG;Rosenbaum, JL
通讯作者：
Rosenbaum, JL