Halo-shaped flowing atmospheric pressure afterglow: a heavenly design for simplified sample introduction and improved ionization in ambient mass spectrometry.
Halo-shaped flowing atmospheric pressure afterglow: a heavenly design for simplified sample introduction and improved ionization in ambient mass spectrometry.
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DOI：
10.1021/ac401524x
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发表时间：
2013-08-06
影响因子：
7.4
通讯作者：
Hieftje, Gary M.
中科院分区：
文献类型：
--
作者：
Pfeuffer, Kevin P.;Schaper, J. Niklas;Shelley, Jacob T.;Ray, Steven J.;Chan, George C-Y.;Bings, Nicolas H.;Hieftje, Gary M.
流动大气压余辉 (FAPA) 是大气压、环境解吸/电离质谱分析的一个有前景的新光源。然而，将可重复的样品引入 FAPA 源中存在问题。为了克服这一限制，开发了一种新的 FAPA 几何结构，其中利用同心管状电极形成晕圈形放电；这种几何形状被称为 halo-FAPA 或 h-FAPA。利用这种新的几何形状，仍然可以实现从表面的直接解吸和电离；然而，通过内部毛细管引入样品也是可能的，并且可以改善样品材料（溶液、蒸气或气溶胶）与等离子体之间的相互作用，从而促进解吸和电离。 h-FAPA 运行时氦气流量为 0.60 L/min 外部流量、0.30 L/min 内部流量、200 V 电压下 30 mA 的施加电流、6 瓦功率。此外，放电本身和样品材料的分离可以防止对等离子体的干扰。光学发射特性和气体旋转温度表明，在溶液-气溶胶样品引入过程中，放电温度并未受到水蒸气的显着影响（450K 时变化< 3%）。主要质谱背景物质是质子化水簇，主要分析物离子是质子化分子离子 (M+H+)。新环境采样源的灵活性通过将其与激光烧蚀装置、同心雾化器和用于样品引入的按需液滴系统耦合来证明。还提出了一种新颖的布置，其中 h-FAPA 的中心通道用作质谱仪的入口。
The flowing atmospheric pressure afterglow (FAPA) is a promising new source for atmospheric pressure, ambient desorption/ionization mass spectrometry. However, problems exist with reproducible sample introduction into the FAPA source. To overcome this limitation, a new FAPA geometry has been developed in which concentric tubular electrodes are utilized to form a halo-shaped discharge; this geometry has been termed the halo-FAPA or h-FAPA. With this new geometry, it is still possible to achieve direct desorption and ionization from a surface; however, sample introduction through the inner capillary is also possible and improves interaction between the sample material (solution, vapor, or aerosol) and the plasma to promote desorption and ionization. The h-FAPA operates with a helium gas flow of 0.60 L/min outer, 0.30 L/min inner, applied current of 30 mA at 200 V for 6 watts of power. In addition, separation of the discharge proper and sample material prevents perturbations to the plasma. Optical-emission characterization and gas rotational temperatures reveal that the temperature of the discharge is not significantly affected (< 3% change at 450K) by water vapor during solution-aerosol sample introduction. The primary mass-spectral background species are protonated water clusters, and the primary analyte ions are protonated molecular ions (M+H+). Flexibility of the new ambient sampling source is demonstrated by coupling it with a laser ablation unit, a concentric nebulizer and a droplet-on-demand system for sample introduction. A novel arrangement is also presented in which the central channel of the h-FAPA is used as the inlet to a mass spectrometer.
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影响因子：
7.4
作者：
Cody, RB;Laramée, JA;Durst, HD
通讯作者：
Durst, HD
影响因子：
7.4
作者：
Shelley, Jacob T.;Ray, Steven J.;Hieftje, Gary M.
通讯作者：
Hieftje, Gary M.
影响因子：
7.4
作者：
BASTIAANS, GJ;HIEFTJE, GM
通讯作者：
HIEFTJE, GM
影响因子：
7.4
作者：
HORNING, EC;HORNING, MG;STILLWELL, RN
通讯作者：
STILLWELL, RN
影响因子：
7.4
作者：
Shelley, Jacob T.;Wiley, Joshua S.;Hieftje, Gary M.
通讯作者：
Hieftje, Gary M.