Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
复制标题
DOI：
10.3389/fphys.2018.00113
复制
发表时间：
2018
影响因子：
4
通讯作者：
Rosales C
中科院分区：
文献类型：
--
作者：
Rosales C
中性粒细胞是循环中最丰富的白细胞，并且被认为是免疫系统先天性手臂中的第一道防线。它们通过吞噬作用和细胞内降解、释放颗粒以及在检测病原体后形成中性粒细胞胞外陷阱来捕获和破坏入侵的微生物。中性粒细胞也作为炎症介质参与。对于这些白细胞的经典观点是中性粒细胞构成具有独特功能的终末分化细胞的同质群体。然而，近年来积累的证据表明，中性粒细胞呈现出很大的表型异质性和功能多样性，这使得中性粒细胞成为炎症和免疫反应的重要调节剂。事实上，中性粒细胞在稳态条件下以及在病理性炎症和免疫过程中所扮演的角色是中性粒细胞生物学中重新关注的焦点。在这篇综述中，我提出了中性粒细胞表型和功能异质性的概念，并描述了迄今报道的几个中性粒细胞亚群。我还讨论了这些亚群似乎在体内平衡和疾病中发挥的作用。
Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as first line of defense in the innate arm of the immune system. They capture and destroy invading microorganisms, through phagocytosis and intracellular degradation, release of granules, and formation of neutrophil extracellular traps after detecting pathogens. Neutrophils also participate as mediators of inflammation. The classical view for these leukocytes is that neutrophils constitute a homogenous population of terminally differentiated cells with a unique function. However, evidence accumulated in recent years, has revealed that neutrophils present a large phenotypic heterogeneity and functional versatility, which place neutrophils as important modulators of both inflammation and immune responses. Indeed, the roles played by neutrophils in homeostatic conditions as well as in pathological inflammation and immune processes are the focus of a renovated interest in neutrophil biology. In this review, I present the concept of neutrophil phenotypic and functional heterogeneity and describe several neutrophil subpopulations reported to date. I also discuss the role these subpopulations seem to play in homeostasis and disease.
登录
查看更多内容
影响因子：
7.5
作者：
Caruso, RA;Bellocco, R;Inferrera, C
通讯作者：
Inferrera, C
影响因子：
7.3
作者：
Berger-Achituv S;Brinkmann V;Abed UA;Kühn LI;Ben-Ezra J;Elhasid R;Zychlinsky A
通讯作者：
Zychlinsky A
影响因子：
5.5
作者：
Buckley, Christopher D.;Ross, Ewan A.;Rainger, G. Ed
通讯作者：
Rainger, G. Ed
DOI：
10.1111/j.1538-7836.2011.04544.x
发表时间：
2012-01
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Brill A;Fuchs TA;Savchenko AS;Thomas GM;Martinod K;De Meyer SF;Bhandari AA;Wagner DD
通讯作者：
Wagner DD
影响因子：
82.9
作者：
Clark, Stephen R.;Ma, Adrienne C.;Kubes, Paul
通讯作者：
Kubes, Paul