Is thermal nociception only sensed by the capsaicin receptor, TRPV1?
Is thermal nociception only sensed by the capsaicin receptor, TRPV1?
复制标题
热伤害感受仅由辣椒素受体 TRPV1 感知吗？
DOI：
10.1007/s12565-009-0048-8
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发表时间：
2009
影响因子：
1.2
通讯作者：
A. Hiura
中科院分区：
文献类型：
--
作者：
A. Hiura
哺乳动物的热痛感知是一个表达TRPV1的初级传入神经元的分子事件。发现了6种热trps，分别是TRPV1-4、TRPM8和TRPA1。前者TRPV1、2和TRPV3、4分别对有毒热和温暖敏感，后两者分别对冷或冷敏感。我们试图提供一种假说来解释TRPV1基因敲除小鼠和辣椒素预处理小鼠严重丢失小背根神经节（DRG）神经元对有害热量表现正常的悖论。一般认为TRPV1在C纤维中优先表达，以应对中等热阈值（>43°C）， TRPV2在a -纤维中优先表达，以应对高阈值温度（>52°C），上述现象令人费解。Woodbury等人（J Neurosci 24:6410-6415, 2004）提出了两种疼痛转导机制，一种是trpv1 /2独立的，另一种是trpv1依赖的。前者在正常情况下不需要TRPV1或TRPV2的存在，而后者在病理生理条件下需要TRPV1的存在。未知的分离素B4 （IB4）阳性但TRPV1阴性的小神经元具有较高的有害热阈值是可行的，因为在人类和大鼠感觉神经元中存在TRPV1的剪接异构体，对有害热（47°C）有反应，但对质子或辣椒素没有反应。因此，ib4阳性但trpv1阴性的小感觉神经元在有害热反应中必须起关键作用。
Mammalian heat pain perception is well documented as a molecular event in the primary afferent neurons expressing TRPV1. Six types of thermo-TRPs were found, i.e., TRPV1–4, TRPM8 and TRPA1. The former TRPV1, 2 and TRPV3, 4 are sensitive to noxious heat and warmth, and the latter two are sensitive to cool or cold, respectively. We attempted to provide a hypothesis to explain the paradox in which TRPV1 knockout mice and capsaicin-pretreated mice with severe loss of small dorsal root ganglion (DRG) neurons behave normally to noxious heat. From the general view that TRPV1 is preferentially expressed in C-fibers responding to a moderate thermal threshold (>43°C) and TRPV2 in Aδ-fibers to high threshold temperatures (>52°C), the above phenomenon is perplexing. Woodbury et al. (J Neurosci 24:6410–6415, 2004) offered two pain transduction mechanisms, one being TRPV1/2-independent and the other TRPV1-dependent. The former detects noxious heat under normal conditions without the presence of TRPV1 or TRPV2, and the latter requires TRPV1 under pathophysiological conditions. Unidentified isolectin B4 (IB4)-positive but TRPV1-negative small neurons with a higher noxious heat threshold are feasible, because a spliced isoform of TRPV1 responsive to noxious heat (47°C) but not responsive to either proton or capsaicin is present in human and rat sensory neurons. Thus, the IB4-positive but TRPV1-negative small sensory neurons must have a crucial role in the noxious heat response.
编码香草酸受体的基因的基因组组织：多种剪接变体的证据。
DOI：
10.1006/geno.2001.6582
发表时间：
2001
期刊：
Genomics.
影响因子：
--
作者：
Xue,Q;Yu,Y;Trilk,SL;Jong,BE;Schumacher,MA
通讯作者：
Schumacher,MA
影响因子：
4
作者：
Lawson, Jeffrey J.;Mcllwrath, Sabrina L.;Koerber, H. Richard
通讯作者：
Koerber, H. Richard