Juxtapapillary Deep-Layer Microvasculature Dropout and Retinal Nerve Fiber Layer Thinning in Glaucoma.
Juxtapapillary Deep-Layer Microvasculature Dropout and Retinal Nerve Fiber Layer Thinning in Glaucoma.
复制标题
青光眼视乳头旁深层微血管脱落和视网膜神经纤维层变薄
DOI：
10.1016/j.ajo.2021.02.014
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发表时间：
2021-07
影响因子：
4.2
通讯作者：
Suh MH
中科院分区：
文献类型：
--
作者：
Kwon JM;Weinreb RN;Zangwill LM;Suh MH
探讨原发性开角型青光眼（POAG）视乳头（JP）和非JP微血管脱落的特征，并比较其视网膜神经纤维层（RNFL）变薄的比率。回顾性队列研究。共纳入了141只POAG患眼，在初始OCT血管造影术（OCT-A）后≥ 2年有≥ 4个连续光学相干断层扫描（OCT）图像。基于OCT-A成像，按年龄和视野平均偏差匹配三组：JP组（与视盘边界接触的乳头旁深层微血管脱落，n=47），非JP组（脱落未达到视盘边界，n=47）和无脱落组（无脱落，n=47）。比较三组间RNFL变薄率。在除颞部和鼻部以外的所有区域，JP组的RNFL变薄速度最快，其次是非JP组和无脱落组。事后分析显示，JP组的RNFL在整体区、颞下区和鼻下区的变薄速度明显快于无脱落组（P < 0.05）。当对以颞下区脱落为主的受试者进行亚组分析时，JP组相应颞下区的RNFL变薄明显快于其他两组（P < 0.001）。JP微血管脱落的眼睛比没有脱落的眼睛表现出更快的RNFL变薄。这些发现表明深层微血管的脱落，特别是与视盘边界接触的微血管的脱落，与青光眼的快速进展有关。
To characterize juxtapapillary (JP) and non-JP microvasculature dropout in primary open-angle glaucoma (POAG) and to compare their rate of retinal nerve fiber layer (RNFL) thinning. Retrospective, cohort study. A total of 141 eyes with POAG with ≥ 4 serial optical coherence tomography (OCT) images after initial OCT angiography (OCT-A) for ≥ 2 years were included. Based on OCT-A imaging, the three groups were matched by age and visual field mean deviation: JP group (parapapillary deep-layer microvasculature dropout in contact with the optic disc boundary, n=47), non-JP group (dropout not reaching the optic disc boundary, n=47), and no-dropout group (lacking the dropout, n=47). RNFL thinning rate was compared among the three groups. The rate of RNFL thinning tended to be fastest in the JP group followed by the non-JP group and no-dropout group in all areas except the temporal and nasal sectors. Post hoc analysis revealed that the JP group had significantly faster RNFL thinning than did the no-dropout group in the global area and the inferotemporal and inferonasal sectors (P < 0.05). When subgroup analysis was performed for subjects in which the main sector of dropout was the inferotemporal sector, the JP group had significantly faster RNFL thinning than the other two groups in the corresponding inferotemporal sector (P < 0.001). Eyes with JP microvasculature dropout showed faster RNFL thinning than eyes without dropout. These findings suggest that deep-layer microvasculature dropout, especially in contact with the optic disc boundary, is associated with rapid glaucoma progression.
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影响因子：
--
作者：
Gandhi M;Dubey S
通讯作者：
Dubey S
影响因子：
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作者：
De Moraes, Carlos Gustavo V.;Juthani, Viral J.;Ritch, Robert
通讯作者：
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影响因子：
4.2
作者：
Kwon, Ji Min;Weinreb, Robert N.;Suh, Min Hee
通讯作者：
Suh, Min Hee
影响因子：
3.7
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通讯作者：
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影响因子：
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作者：
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