Potential preventive strategies and therapies in urinary tract infection

Potential preventive strategies and therapies in urinary tract infection
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尿路感染的潜在预防策略和治疗

DOI:
10.1007/s003450050161
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发表时间:
1999
影响因子:
3.4
通讯作者:
G. Reid
G. Reid
中科院分区:
医学2区
文献类型:
--
作者:
G. Reid

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目前可能有五种策略被提倡或正在研究预防复发性尿路感染(UTI):抗生素,包括天然肽;功能食品;疫苗;益生菌;和杂项,包括避免使用杀精剂和保持良好的卫生。不可能说明使用抗生素与食用蔓越莓等食物或使用替代方法(如避免使用杀精剂)的患者比例。大多数被转诊到专科医生那里的妇女都会得到长期低剂量抗生素的处方。然而,考虑到问题的严重性,可以肯定地说,大量妇女至少正在尝试替代疗法,如饮用蔓越莓汁或服用草药,以增强她们的免疫反应。疫苗的开发距离人类使用还有很长的路要走,而且还没有针对大肠杆菌以外的生物体开发疫苗。使用益生菌来恢复正常的阴道菌群,并为病原体提供一个竞争性的细菌屏障,即将成为一种替代的预防方法。今后十年应采用新的方法来降低尿路感染的高发率,并更好地管理复发性泌尿生殖系统感染。
Abstract There are perhaps five strategies either presently advocated or under investigation for prevention of recurrent urinary tract infection (UTI): antibiotics, including natural peptides; functional foods; vaccines; probiotics; and miscellaneous, including avoidance of spermicides and maintenance of good hygiene. It is not possible to state the proportion of patients using antibiotics versus foods such as cranberry or using alternative approaches such as avoidance of spermicides. The majority of women who are referred to specialists will be prescribed long-term, low-dose antibiotics. However, given the magnitude of the problem, it is safe to state that large numbers of women are at least experimenting with alternative remedies such as drinking of cranberry juice or ingestion of herbal remedies with a view to enhancing their immune response. Vaccine development remains a long way from human use and has yet to be developed for organisms other than Escherichia coli. The use of probiotics to restore the normal vaginal flora and provide a competitive bacterial barrier to pathogens is close to becoming available as an alternative preventive approach. The next decade should see the introduction of new methods for reduction of the high incidence of UTI and better management of recurring urogenital infections.
DOI: --
发表时间: 1984
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