Predicting Promiscuous T Cell Epitopes for Designing a Vaccine Against Streptococcus pyogenes.
Predicting Promiscuous T Cell Epitopes for Designing a Vaccine Against Streptococcus pyogenes.
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预测针对化脓性链球菌设计疫苗的混杂T细胞表位。
DOI：
10.1007/s12010-018-2804-5
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发表时间：
2019-01
影响因子：
3
通讯作者：
Behbahani M
中科院分区：
文献类型：
--
作者：
Ebrahimi S;Mohabatkar H;Behbahani M
化脓性链球菌是世界范围内流行率最高的最危险的人类病原体之一，它对全球发病率和死亡率有重大影响。化脓性葡萄球菌疫苗开发的一个主要挑战是检测具有保护作用的表位，使其免受多种化脓性葡萄球菌感染。我们的目的是鉴定化脓性链球菌最保守的免疫原性抗原，这可能是未来疫苗设计的潜在候选抗原。分析了8种重要的表面蛋白。使用不同的预测服务器，选择最强的表位。它们有能力刺激体液和细胞介导的免疫系统。通过分子对接测定所选表位的自由结合能。从3种表面蛋白中选出7个表位作为疫苗开发的潜在候选。对所选表位在不同链球菌类型中的保守性进行了检查。需要进一步的体外和体内试验来验证抗原表位在疫苗设计中的适用性。
One of the most dangerous human pathogens with high prevalence worldwide is Streptococcus pyogenes, which has major impacts on global morbidity and mortality. A major challenge for S. pyogenes vaccine development is the detection of epitopes that confer protection from infection by multiple S. pyogenes types. Our aim was to identify the most conserved and immunogenic antigens of S. pyogenes, which can be a potential candidate for vaccine design in the future. Eight important surface proteins were analyzed. Using different prediction servers, strongest epitopes were selected. They had the ability to stimulate the humoral and cell-mediated immune system. Molecular docking was performed for measuring free-binding energy of selected epitopes. Seven epitopes from three surface proteins were selected as potential candidates for vaccine development. Conservation of selected epitopes among different Streptococcus types was checked. Further in vitro and in vivo tests are required to validate the suitability of the epitopes for vaccine design.
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