A tissue-like neurotransmitter sensor for the brain and gut.
A tissue-like neurotransmitter sensor for the brain and gut.
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DOI：
10.1038/s41586-022-04615-2
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发表时间：
2022-06
期刊：
影响因子：
64.8
通讯作者：
中科院分区：
文献类型：
--
作者：
神经递质在调节中枢神经系统以及外周（包括胃肠道）的神经回路动力学中起重要作用。它们的实时监测将为理解神经功能和诊断疾病提供关键信息。然而，用于监测体内神经递质，特别是肠神经系统中神经递质动态的生物电子工具还不发达。这主要是由于能够探测柔软、复杂和主动移动器官的生物传感工具的可用性有限。在这里，我们介绍了一种组织模仿，可拉伸的神经化学生物界面称为NeuroString，它是通过激光图案化的金属络合聚酰亚胺到嵌入在弹性体中的互连石墨烯/纳米颗粒网络。NeuroString传感器允许在行为小鼠的大脑中进行长期的体内实时、多通道和多路单胺传感，以及测量肠道中的血清素动力学，而不会产生不期望的刺激和干扰蠕动运动。所描述的弹性和顺应性生物传感接口具有广泛的潜力，用于研究神经递质对肠道微生物的影响，脑-肠通信，并可能最终扩展到身体其他软器官中的生物分子传感。
Neurotransmitters play essential roles in regulating neural circuit dynamics both in the central nervous system as well as at the peripheral, including the gastrointestinal tract. Their real-time monitoring will offer critical information for understanding neural function and diagnosing disease. However, bioelectronic tools to monitor the dynamics of neurotransmitters in vivo, especially in the enteric nervous systems, are underdeveloped. This is mainly due to the limited availability of biosensing tools that are capable of probing soft, complex, and actively moving organs. Here, we introduce a tissue-mimicking, stretchable neurochemical biointerface termed NeuroString, which is prepared by laser-patterning of a metal-complexed polyimide into an interconnected graphene/nanoparticle network embedded in an elastomer. NeuroString sensors allow chronic in vivo real-time, multichannel and multiplexed monoamine sensing in the brain of behaving mouse, as well as measuring serotonin dynamics in the gut without undesired stimulations and perturbing peristaltic movements. The described elastic and conformable biosensing interface has broad potential for studying the impact of neurotransmitters on gut microbes, brain-gut communication, and may ultimately be extended to biomolecular sensing in other soft organs across the body.
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DOI：
10.1073/pnas.1513619112
发表时间：
2016-01-05
影响因子：
11.1
作者：
Kishida, Kenneth T.;Saez, Ignacio;Montague, P. Read
通讯作者：
Montague, P. Read
影响因子：
56.9
作者：
Minev, Ivan R.;Musienko, Pavel;Lacour, Stephanie P.
通讯作者：
Lacour, Stephanie P.
DOI：
10.1152/ajpgi.90375.2008
发表时间：
2008-12-01
影响因子：
4.5
作者：
Bertrand, Paul P.;Hu, Xiaoya;Bertrand, Rebecca L.
通讯作者：
Bertrand, Rebecca L.
影响因子：
48
作者：
Clark, Jeremy J.;Sandberg, Stefan G.;Wanat, Matthew J.;Gan, Jerylin O.;Horne, Eric A.;Hart, Andrew S.;Akers, Christina A.;Parker, Jones G.;Willuhn, Ingo;Martinez, Vicente;Evans, Scott B.;Stella, Nephi;Phillips, Paul E. M.
通讯作者：
Phillips, Paul E. M.
DOI：
10.1016/j.vascn.2011.03.003
发表时间：
2011-07-01
影响因子：
1.9
作者：
Lynch, James J., III;Castagne, Vincent;Mittelstadt, Scott W.
通讯作者：
Mittelstadt, Scott W.