Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma.
Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma.
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DOI：
10.1186/bcr627
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Nagawa H
中科院分区：
文献类型：
--
作者：
Kato M;Kitayama J;Kazama S;Nagawa H
基质细胞衍生因子-1/CXC趋化因子受体-4（SDF-1/CXCR 4）信号已被证明在各种免疫反应中是重要的。最近的研究表明，CXCR 4在某些癌细胞中表达，并且它们有效地利用这种趋化因子受体来形成转移。应用免疫组织化学方法检测79例浸润性导管癌中CXCR 4的表达，并分析其与临床病理特征的关系。CXCR 4在59例癌组织中呈弥漫性和均匀性表达，根据染色强度将其进一步分为28例高表达和31例低表达癌。其余20例肿瘤组织呈不均一性免疫反应，定义为局灶型。与弥漫型相比，局灶型肿瘤表现出更广泛的淋巴结转移，因为局灶型的转移淋巴结数量和范围均大于弥漫型。在弥漫型中，淋巴结阳性病例的比率在染色强度上没有显示出差异。然而，与低表达肿瘤相比，高CXCR 4肿瘤显示更广泛的淋巴结转移。相反，CXCR 4的表达模式与血行转移无明显相关性。这些患者的总生存率在弥漫型中往往好于局灶型，尽管差异无统计学意义。CXCR 4的表达与乳腺癌的淋巴结转移密切相关。我们的数据表明，CXCR 4可能是特别重要的促进通过淋巴系统转移。
The stromal cell-derived factor-1/CXC chemokine receptor-4 (SDF-1/CXCR4) signal has been shown to be important in various immunological reactions. Recent studies have suggested that CXCR4 is expressed in certain cancer cells and that they use this chemokine receptor efficiently for metastasis formation. The expression of CXCR4 was evaluated by immunohistochemical study in 79 surgically resected invasive ductal carcinomas, and the relation between the staining pattern and clinicopathological features was examined. CXCR4 was diffusely and homogeneously expressed in 59 cancers, which were further divided into 28 high-expression and 31 low-expression cancers by their staining intensity. The other 20 cancers showed heterogeneous immunoreactivity in tumor tissue, which was defined as focal type. In comparison with the diffuse type, focal type tumors showed significantly more extensive lymph node metastasis, because the number and extent of metastatic nodes were larger in the focal than the diffuse type. In the diffuse type, the rate of node-positive cases did not show a difference in staining intensity. However, high-CXCR4 tumors showed more extensive nodal metastasis in comparison with low-expression tumors. In contrast, the expression pattern of CXCR4 did not have a significant correlation with hematogeneous metastasis. The overall survival of these patients tended to be better in the diffuse type than in the focal type, although the difference was not statistically significant. The expression pattern of CXCR4 was significantly correlated with the degree of lymph node metastasis in breast cancers. Our data suggest that CXCR4 might be particularly important in facilitating metastasis through the lymphatic system.
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3.1
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