Increased levels of TAR DNA-binding protein 43 in the hippocampus of subjects with bipolar disorder: a postmortem study.
Increased levels of TAR DNA-binding protein 43 in the hippocampus of subjects with bipolar disorder: a postmortem study.
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DOI：
10.1007/s00702-021-02455-4
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发表时间：
2022-01
影响因子：
3.3
通讯作者：
Lafer, Beny
中科院分区：
文献类型：
--
作者：
Nascimento, Camila;Nunes, Paula, V;Kim, Helena K.;Leite, Renata E. P.;Rodriguez, Roberta D.;De Oliveira, Katia Cristina;Brentani, Helena P.;Jacob-Filho, Wilson;Nitrini, Ricardo;Pasqualucci, Carlos A.;Grinberg, Lea T.;Suemoto, Claudia K.;Lafer, Beny
关键词：
双相AQ 1 AQ 2 AQ 3障碍与其他神经退行性疾病（包括额颞叶痴呆（FTD））有相同的症状和病理途径。由于TAR DNA结合蛋白43（TDP-43）是额颞叶痴呆的神经病理学标志物，它参与突触传递，我们探讨了TDP-43作为双相情感障碍（BD）的分子特征的作用。从双相情感障碍受试者死后大脑的冷冻海马获得匀浆。TDP-43水平定量使用ELISA夹心法，并在双相情感障碍受试者和年龄匹配的对照组的死后大脑之间进行比较。与对照组（n = 15）相比，我们发现BD（n = 15）受试者海马中TDP-43蛋白水平较高。我们没有发现TDP-43与死亡年龄，死后间隔或疾病发作年龄的关联。我们的研究结果表明，蛋白TDP-43可能是潜在的牵连行为异常看到BD。需要进一步的研究来验证这些发现，并检查AQ 4这种蛋白质在疾病过程和情绪状态中的作用。
Bipolar AQ1 AQ2 AQ3 disorder shares symptoms and pathological pathways with other neurodegenerative diseases, including frontotemporal dementia (FTD). Since TAR DNA-binding protein 43 (TDP-43) is a neuropathological marker of frontotemporal dementia and it is involved in synaptic transmission, we explored the role of TDP-43 as a molecular feature of bipolar disorder (BD). Homogenates were acquired from frozen hippocampus of postmortem brains of bipolar disorder subjects. TDP-43 levels were quantified using an ELISA-sandwich method and compared between the postmortem brains of bipolar disorder subjects and age-matched control group. We found higher levels of TDP-43 protein in the hippocampus of BD (n = 15) subjects, when compared to controls (n = 15). We did not find associations of TDP-43 with age at death, postmortem interval, or age of disease onset. Our results suggest that protein TDP-43 may be potentially implicated in behavioral abnormalities seen in BD. Further investigation is needed to validate these findings and to examine AQ4 the role of this protein during the disease course and mood states.
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影响因子：
11
作者：
Cao B;Passos IC;Mwangi B;Amaral-Silva H;Tannous J;Wu MJ;Zunta-Soares GB;Soares JC
通讯作者：
Soares JC
影响因子：
9.9
作者：
Cummings, JL
通讯作者：
Cummings, JL
影响因子：
12.8
作者：
Lee Y;Zhang Y;Kim S;Han K
通讯作者：
Han K
影响因子：
6.8
作者：
Darby MM;Yolken RH;Sabunciyan S
通讯作者：
Sabunciyan S
DOI：
10.1159/000470803
发表时间：
2017-01-01
期刊：
Modern trends in pharmacopsychiatry
影响因子：
--
作者：
Bauer, Isabelle E;Soares, Jair C;Meyer, Thomas D
通讯作者：
Meyer, Thomas D