Hippocampal subfield volumes in mood disorders.
Hippocampal subfield volumes in mood disorders.
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DOI：
10.1038/mp.2016.262
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发表时间：
2017-09
影响因子：
11
通讯作者：
Soares JC
中科院分区：
文献类型：
--
作者：
Cao B;Passos IC;Mwangi B;Amaral-Silva H;Tannous J;Wu MJ;Zunta-Soares GB;Soares JC
海马体的体积减小和形状异常与情绪障碍有关。然而，海马不是一个统一的结构，并由几个子域组成，如角氨（CA）子域CA 1 -4，齿状回（DG）包括颗粒细胞层（GCL）和分子层（ML），连续穿过相邻的下托和CA领域。众所周知，与情绪障碍相关的细胞和分子机制可能局限于特定的海马亚区。因此，有必要研究体内海马子域体积与特定情绪障碍（如双相情感障碍（BD）和重度抑郁症（MDD））之间的联系。在本研究中，我们使用了最先进的海马分割方法，我们发现与健康受试者和MDD患者相比，BD患者的海马子域体积减少，特别是在左侧CA 4，GCL，ML和海马尾两侧。容量减少在双相I型障碍（BD-I）患者中尤为严重。我们还证明海马子区体积减少与疾病的进展有关。BD-I患者右侧CA 1、ML和Sub体积随病程增加而减小，两侧CA 2/3、CA 4和海马尾体积与躁狂发作次数呈负相关。结果提示，在心境障碍中，BD-I对海马各亚区的影响较BD-II和MDD更为显著，躁狂发作对海马CA 2/3、CA 4区和海马尾区的影响更集中。
Volume reduction and shape abnormality of the hippocampus have been associated with mood disorders. However, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (CA) subfields CA1–4, the dentate gyrus (DG) including a granule cell layer (GCL) and a molecular layer (ML) that continuously crosses adjacent subiculum and CA fields. It is known that cellular and molecular mechanisms associated with mood disorders may be localized to specific hippocampal subfields. Thus, it is necessary to investigate the link between the in vivo hippocampal subfield volumes and specific mood disorders, such as bipolar disorder (BD) and major depressive disorder (MDD). In the present study, we used a state-of-the-art hippocampal segmentation approach, and we found that patients with BD had reduced volumes of hippocampal subfields, specifically in the left CA4, GCL, ML, and both sides of the hippocampal tail, compared to healthy subjects and patients with MDD. The volume reduction was especially severe in patients with bipolar I disorder (BD-I). We also demonstrated that hippocampal subfield volume reduction was associated with the progression of the illness. For patients with BD-I, the volumes of the right CA1, ML and Sub decreased as the illness duration increased, and the volumes of both sides of the CA2/3, CA4, and hippocampal tail had negative correlations with the number of manic episodes. These results indicated that among the mood disorders the hippocampal subfields were more affected in BD-I compared to BD-II and MDD, and manic episodes had focused progressive effect on the CA2/3 and CA4 and hippocampal tail.
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影响因子：
11
作者：
Hibar, D. P.;Westlye, L. T.;van Erp, T. G. M.;Rasmussen, J.;Leonardo, C. D.;Faskowitz, J.;Haukvik, U. K.;Hartberg, C. B.;Doan, N. T.;Agartz, I.;Dale, A. M.;Gruber, O.;Kraemer, B.;Trost, S.;Liberg, B.;Abe, C.;Ekman, C. J.;Ingvar, M.;Landen, M.;Fears, S. C.;Freimer, N. B.;Bearden, C. E.;Sprooten, E.;Glahn, D. C.;Pearlson, G. D.;Emsell, L.;Kenney, J.;Scanlon, C.;McDonald, C.;Cannon, D. M.;Almeida, J.;Versace, A.;Caseras, X.;Lawrence, N. S.;Phillips, M. L.;Dima, D.;Delvecchio, G.;Frangou, S.;Satterthwaite, T. D.;Wolf, D.;Houenou, J.;Henry, C.;Malt, U. F.;Boen, E.;Elvsashagen, T.;Young, A. H.;Lloyd, A. J.;Goodwin, G. M.;Mackay, C. E.;Bourne, C.;Bilderbeck, A.;Abramovic, L.;Boks, M. P.;van Haren, N. E. M.;Ophoff, R. A.;Kahn, R. S.;Bauer, M.;Pfennig, A.;Alda, M.;Hajek, T.;Mwangi, B.;Soares, J. C.;Nickson, T.;Dimitrova, R.;Sussmann, J. E.;Hagenaars, S.;Whalley, H. C.;McIntosh, A. M.;Thompson, P. M.;Andreassen, O. A.
通讯作者：
Andreassen, O. A.
影响因子：
7.6
作者：
Bearden, Carrie E.;Thompson, Paul M.;Soares, Jair C.
通讯作者：
Soares, Jair C.
影响因子：
2.3
作者：
Caetano, SC;Hatch, JP;Soares, JC
通讯作者：
Soares, JC
影响因子：
--
作者：
Blumberg, HP;Kaufman, J;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
11
作者：
Eastwood, SL;Harrison, PJ
通讯作者：
Harrison, PJ