A Preliminary Study of Geographic Influence on Arsenic Concentrations in Human Hair
A Preliminary Study of Geographic Influence on Arsenic Concentrations in Human Hair
复制标题
地理对人类头发中砷浓度影响的初步研究
DOI：
10.1023/a:1006590827264
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发表时间：
1998
影响因子：
4.2
通讯作者：
D. Lane
中科院分区：
文献类型：
--
作者：
D. F. Peach;D. Lane
过去在英国康沃尔郡的采矿活动使当地环境暴露在砷水平升高的环境中。以前的研究表明，在这些地区种植的农作物中砷浓度增加，随后通过食物链吸收砷可能会导致人体负担增加。为了评估这一点，进行了一项试点研究，使用粒子诱导X射线发射来比较一组康沃尔居民和一组由牛津郡和威尔特郡居民组成的对照组的头发浓度。零假设是两组的头发浓度没有显著差异。每组包括36名年龄和性别匹配的受试者。康尼什组的头发砷平均浓度为2.51μg g-1，显著高于对照组的0.7μg g-1(p=0.004)。世界卫生组织建议头发AS值大于1μg g-1作为砷暴露增加的证据，加拿大政府引用5μg g-1作为大量摄入As的证据。21名康沃尔受试者的G值等于或高于1μg为g-1，而对照组为9人(p=0.0003)。康尼什组中有5名受试者的值超过5μg as g-1，而对照组中只有2名(p=0.23)。我们利用这项研究的结果作为证据，支持我们在这一领域的继续工作，以评估可能对健康的影响。
Past mining activities in the county of Cornwall in the United Kingdom, has exposed the local environment to raised levels of As. Previous research has shown an increased concentration of As in crops grown in such areas and the subsequent take-up of As through the food chain may lead to an increased body burden in man. In an attempt to evaluate this, a pilot study was carried out using Particle Induced X-ray Emission to compare the hair As concentration of a group of Cornish residents to that of a control group consisting of residents in the counties of Oxfordshire and Wiltshire. The null hypothesis being that there is no significant difference between the hair As concentrations of the two groups.Each group comprised thirty six age and sex matched subjects. The mean hair As concentration for the Cornish group was 2.51 μg g-1, which is significantly greater than that of 0.7 μg g-1 found in the control group (p = 0.004). The World Health Organisation suggests a hair As value greater than 1 μg g-1 as evidence of increased exposure to As and 5 μg g-1 is quoted by the Canadian Government as evidence of significant ingestion of As. Twenty one Cornish subjects registered a value at or above 1 μg As g-1 compared to nine in the control group (p = 0.0003). Five subjects in the Cornish group had values that exceed 5 μg As g-1, compared to only two in the control group (p = 0.23). We use the results of this study as evidence to support our continued work in this area in order to evaluate possible health implications.
影响因子：
10.4
作者：
Smith AH;Hopenhayn-Rich C;Bates MN;Goeden HM;Hertz-Picciotto I;Duggan HM;Wood R;Kosnett MJ;Smith MT
通讯作者：
Smith MT