Regulatory patterns analysis of transcription factor binding site clustered regions and identification of key genes in endometrial cancer.
Regulatory patterns analysis of transcription factor binding site clustered regions and identification of key genes in endometrial cancer.
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DOI：
10.1016/j.csbj.2022.01.014
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发表时间：
2022
影响因子：
6
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Tang X;Wang J;Tao H;Yuan L;Du G;Ding Y;Xu K;Bai X;Li Y;Sun Y;Huang X;Zheng X;Li Q;Gong B;Zheng Y;Xu J;Xu X;Wang Z;Bo X;Lu M;Li H;Chen H
子宫内膜癌是女性生殖系统的三大恶性肿瘤之一。表观遗传学改变在肿瘤发生中起重要作用，尤其是染色质可及性改变和转录因子结合差异。然而，EC发展中表观遗传改变的调控机制仍不清楚。在这里，我们确定和特点转录因子结合位点簇集区（TFCR），通过整合染色质可及性和转录因子结合信息。我们共鉴定了78，820个TFCR，并探讨了TFCR与调控元件、基因表达和突变的关系。最后，我们构建了一个生物信息学框架，以确定候选癌基因，并筛选出13个候选关键基因，这些基因可能作为潜在的诊断标志物或治疗靶点EC。
Endometrial cancer (EC) is one of the three fatal tumors of the female reproductive system. Epigenetic alterations have been reported to be important in tumorigenesis, especially the chromatin accessibility changes and transcription factor binding differences. However, the regulatory mechanism underlying epigenetic alterations in EC development remains unclear. Here, we identified and characterized transcription factor binding site clustered regions (TFCRs) by integrating chromatin accessibility and transcription factor binding information. We totally identified 78,820 TFCRs and explored the relationship between TFCRs and regulatory elements, gene expression and mutation. Finally, we constructed a bioinformatic framework to identify candidate oncogenes and screened 13 candidate key genes, which may serve as potential diagnostic markers or therapeutic targets of EC.
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相位分离驱动异常的染色质循环和癌症发展。
影响因子：
64.8
作者：
Ahn JH;Davis ES;Daugird TA;Zhao S;Quiroga IY;Uryu H;Li J;Storey AJ;Tsai YH;Keeley DP;Mackintosh SG;Edmondson RD;Byrum SD;Cai L;Tackett AJ;Zheng D;Legant WR;Phanstiel DH;Wang GG
通讯作者：
Wang GG
iFORM：结合查找监管主题的出现。
影响因子：
3.7
作者：
Ren C;Chen H;Yang B;Liu F;Ouyang Z;Bo X;Shu W
通讯作者：
Shu W
DOI：
10.1158/1078-0432.ccr-20-0953
发表时间：
2020-08-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Fader AN;Roque DM;Siegel E;Buza N;Hui P;Abdelghany O;Chambers S;Secord AA;Havrilesky L;O'Malley DM;Backes FJ;Nevadunsky N;Edraki B;Pikaart D;Lowery W;ElSahwi K;Celano P;Bellone S;Azodi M;Litkouhi B;Ratner E;Silasi DA;Schwartz PE;Santin AD
通讯作者：
Santin AD
影响因子：
30.8
作者：
Cheng TH;Thompson DJ;O'Mara TA;Painter JN;Glubb DM;Flach S;Lewis A;French JD;Freeman-Mills L;Church D;Gorman M;Martin L;National Study of Endometrial Cancer Genetics Group (NSECG);Hodgson S;Webb PM;Australian National Endometrial Cancer Study Group (ANECS);Attia J;Holliday EG;McEvoy M;Scott RJ;Henders AK;Martin NG;Montgomery GW;Nyholt DR;Ahmed S;Healey CS;Shah M;Dennis J;Fasching PA;Beckmann MW;Hein A;Ekici AB;Hall P;Czene K;Darabi H;Li J;Dörk T;Dürst M;Hillemanns P;Runnebaum I;Amant F;Schrauwen S;Zhao H;Lambrechts D;Depreeuw J;Dowdy SC;Goode EL;Fridley BL;Winham SJ;Njølstad TS;Salvesen HB;Trovik J;Werner HM;Ashton K;Otton G;Proietto T;Liu T;Mints M;Tham E;RENDOCAS;Consortium C;Jun Li M;Yip SH;Wang J;Bolla MK;Michailidou K;Wang Q;Tyrer JP;Dunlop M;Houlston R;Palles C;Hopper JL;AOCS Group;Peto J;Swerdlow AJ;Burwinkel B;Brenner H;Meindl A;Brauch H;Lindblom A;Chang-Claude J;Couch FJ;Giles GG;Kristensen VN;Cox A;Cunningham JM;Pharoah PDP;Dunning AM;Edwards SL;Easton DF;Tomlinson I;Spurdle AB
通讯作者：
Spurdle AB
影响因子：
4.7
作者：
Aghajanian C;Filiaci V;Dizon DS;Carlson JW;Powell MA;Secord AA;Tewari KS;Bender DP;O'Malley DM;Stuckey A;Gao J;Dao F;Soslow RA;Lankes HA;Moore K;Levine DA
通讯作者：
Levine DA