Evolution and Clinical Translation of Drug Delivery Nanomaterials.
Evolution and Clinical Translation of Drug Delivery Nanomaterials.
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DOI：
10.1016/j.nantod.2017.06.008
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发表时间：
2017-08
期刊：
影响因子：
17.4
通讯作者：
Khademhosseini A
中科院分区：
文献类型：
--
作者：
Hassan S;Prakash G;Ozturk A;Saghazadeh S;Sohail MF;Seo J;Dockmeci M;Zhang YS;Khademhosseini A
随着技术的出现，纳米材料在医学中的作用在过去几十年中呈指数级增长。这种材料的主要优点已经在药物递送应用中被利用，这是由于它们的有效靶向，与常规的药物施用途径相比，这又降低了全身毒性。尽管这些材料基于靶向组织、疾病和药物有效载荷提供了广泛的灵活性，但对更有效且高度生物相容性的纳米材料药物的需求正在增加。虽然在纳米医学平台中引入了治疗上改进和安全的材料，但与其降解速率和生物分布相关的问题仍然存在，因此使其成功转化为人类使用非常具有挑战性。研究人员正在不断改进新型纳米材料，这些材料不仅作为治疗剂而且作为诊断工具更安全，更有效，使纳米医学领域的研究更加迷人。在这篇综述中，重点介绍了美国食品药品监督管理局（FDA）批准用于临床应用的纳米材料的演变。
With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their effective targeting that in turn reduces systemic toxicity compared to the conventional routes of drug administration. Even though these materials offer broad flexibility based on targeting tissue, disease, and drug payload, the demand for more effective yet highly biocompatible nanomaterial-based drugs is increasing. While therapeutically improved and safe materials have been introduced in nanomedicine platforms, issues related to their degradation rates and bio-distribution still exist, thus making their successful translation for human use very challenging. Researchers are constantly improving upon novel nanomaterials that are safer and more effective not only as therapeutic agents but as diagnostic tools as well, making the research in the field of nanomedicine ever more fascinating. In this review stress has been made on the evolution of nanomaterials that have been approved for clinical applications by the United States Food and Drug Administration Agency (FDA).
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影响因子：
8
作者：
Bozzuto G;Molinari A
通讯作者：
Molinari A
用于研究药物输送系统的器官片平台。
DOI：
10.1016/j.jconrel.2014.05.004
发表时间：
2014-09-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Bhise NS;Ribas J;Manoharan V;Zhang YS;Polini A;Massa S;Dokmeci MR;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
9.7
作者：
Cheng, Chih-Chia;Chang, Feng-Chih;Lee, Duu-Jong
通讯作者：
Lee, Duu-Jong
影响因子：
5.8
作者：
Chang, Cong;Wei, Hua;Zhuo, Ren-Xi
通讯作者：
Zhuo, Ren-Xi
基于金簇的多功能近红外发射纳米缀合物用于肿瘤成像和治疗
影响因子：
14
作者：
Chen, Haiyan;Li, Bowen;Gu, Yueqing
通讯作者：
Gu, Yueqing