New tools for quantifying HIV-1 reservoirs: plasma RNA single copy assays and beyond.
New tools for quantifying HIV-1 reservoirs: plasma RNA single copy assays and beyond.
复制标题
DOI：
10.1007/s11904-011-0104-6
复制
发表时间：
2012-03
影响因子：
4.6
通讯作者：
Mellors, John W.
中科院分区：
文献类型：
--
作者：
Hilldorfer, Benedict B.;Cillo, Anthony R.;Besson, Guillaume J.;Bedison, Margaret Anne;Mellors, John W.
关键词：
Quantification of plasma HIV-1 RNA below the limit of FDA-approved assays by a single copy quantitative PCR assays (SCA) has provided significant insights into HIV-1 persistence despite potent antiretroviral therapy as well as a means to assess the impact of therapeutic strategies, such as treatment intensification, on residual viremia. In this review, we discuss insights gained from plasma HIV-1 RNA SCA and highlight the need for additional assays to characterize better the cellular and tissue reservoirs of HIV-1. Accurate, reproducible, and sensitive assays to quantify HIV-1 reservoirs, before and after therapeutic interventions, are essential tools in the quest for a cure of HIV-1 infection.
登录
查看更多内容
影响因子：
5.4
作者：
Havlir, DV;Strain, MC;Wong, JK
通讯作者：
Wong, JK
影响因子：
6.4
作者：
Hatano, Hiroyu;Hayes, Timothy L.;Deeks, Steven G.
通讯作者：
Deeks, Steven G.
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
64.8
作者：
Chun, TW;Carruth, L;Siliciano, RF
通讯作者：
Siliciano, RF
影响因子：
5.4
作者：
Anderson, Jeffrey A.;Archin, Nancie M.;Margolis, David M.
通讯作者：
Margolis, David M.