Primate evolution of the recombination regulator PRDM9.
Primate evolution of the recombination regulator PRDM9.
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DOI：
10.1038/ncomms5370
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发表时间：
2014-07-08
影响因子：
16.6
通讯作者：
Shendure, Jay
中科院分区：
文献类型：
--
作者：
Schwartz, Jerrod J.;Roach, David J.;Thomas, James H.;Shendure, Jay
The PRDM9 gene encodes a protein with a highly variable tandem-repeat zinc finger (ZF) DNA-binding domain that plays a key role in determining sequence-specific hotspots of meiotic recombination genome-wide. Here we survey the diversity of the PRDM9 ZF domain by sequencing this region in 64 primates from 18 species, revealing 68 unique alleles across all groups. We report ubiquitous positive selection at nucleotide positions corresponding to DNA contact residues and the expansion of ZFs within clades, which confirms the rapid evolution of the ZF domain throughout the primate lineage. Alignment of Neanderthal and Denisovan sequences suggests that PRDM9 in archaic hominins was closely related to present-day human alleles that are rare and specific to African populations. In the context of its role in reproduction, our results are consistent with variation in PRDM9 contributing to speciation events in primates.
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DOI：
10.1093/bioinformatics/btr064
发表时间：
2011-04-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Grant CE;Bailey TL;Noble WS
通讯作者：
Noble WS
DOI：
10.1126/science.1224344
发表时间：
2012-10-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Meyer M;Kircher M;Gansauge MT;Li H;Racimo F;Mallick S;Schraiber JG;Jay F;Prüfer K;de Filippo C;Sudmant PH;Alkan C;Fu Q;Do R;Rohland N;Tandon A;Siebauer M;Green RE;Bryc K;Briggs AW;Stenzel U;Dabney J;Shendure J;Kitzman J;Hammer MF;Shunkov MV;Derevianko AP;Patterson N;Andrés AM;Eichler EE;Slatkin M;Reich D;Kelso J;Pääbo S
通讯作者：
Pääbo S
影响因子：
64.8
作者：
通讯作者：
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PRDM9物种形成基因在多种后生分类单元中加速了进化。
影响因子：
4.5
作者：
Oliver PL;Goodstadt L;Bayes JJ;Birtle Z;Roach KC;Phadnis N;Beatson SA;Lunter G;Malik HS;Ponting CP
通讯作者：
Ponting CP
影响因子：
2.4
作者：
Nagy, Sandor;Poczai, Peter;Taller, Janos
通讯作者：
Taller, Janos